Metoprolol identification

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  1. Metoprolol identification


    To rapidly identify Metoprolol Tartrate tablets from different manufacturers, a qualitative analysis model can be established by near infrared spectroscopy. Firstly, Antaris II Fourier-transform near infrared (FT-NIR) spectroscopy and Micro NIR1700 Spectrometer were used to collect spectral data of 66 batches of samples which come from four different manufacturers, then 44 samples of calibration set and 22 samples of validation set were acquired by random sampling. In order to build up a PLS-DA model, the first derivative with Savitzky-Golay 15 points smoothing (1d SG15) and standard normal vitiate transformation (SNV) was selected as the pretreatment method and according to the variation between different samples and the characteristic absorption band, 6 468-7 104 cm(-1) and 6 468-7 156 cm(-1) were chosen as the modeling spectra region. The confusion matrix indicated that Metoprolol Tartrate tablets could be rapidly and effectively identified by two analytical models, which were established using the spectral data collected from two instruments. For these two models, both of the sensitivity and specificity were 100%. This study confirmed that it is feasible to carry out the manufacturer identification of Metoprolol Tartrate tablets by near infrared spectroscopy. Besides, the use of Micro NIR1700 Spectrometer, which is the minimum and portable near infrared spectrometer, provides valuable insights for fast on-site drug screening. Metoprolol is a cardioselective β1-adrenergic blocking agent used for acute myocardial infarction (MI), heart failure, angina pectoris and mild to moderate hypertension. It may also be used for supraventricular and tachyarrhythmias and prophylaxis for migraine headaches. Metoprolol is structurally similar to bisoprolol, acebutolol and atenolol in that it has two substituents in the para position of the benzene ring. The β1-selectivity of these agents is thought to be due in part to the large substituents in the para position. At low doses, metoprolol selectively blocks cardiac β1-adrenergic receptors with little activity against β2-adrenergic receptors of the lungs and vascular smooth muscle. Unlike propranolol and pindolol, metoprolol does not exhibit membrane-stabilizing or intrinsic sympathomimetic activity. Membrane-stabilizing effects are only observed at doses much higher than those needed for β-adrenergic blocking activity. Metoprolol possesses a single chiral centre and is administered as a racemic mixture.

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    Metoprolol MPL is a chiral β-blocker ubiquitously detected in various environments. analytical method was developed to identify transformation products TPs. Metoprolol Tartrate by Sun Pharmaceutical Industries, Inc. is a white rou tablet about 8 mm in size, imprinted with 477. The product is a human prescription drug. Find patient medical information for Metoprolol Tartrate Oral on WebMD including its uses, side effects and safety, interactions, pictures, warnings and user.

    Our prescription savings may even be lower than your insurance copay! Note: Multiple images may be displayed for medicines available in different strengths, sold under different brand names, or manufactured by different pharmaceutical companies. prescription and over-the-counter drugs (OTC) are required to have an imprint. If you have questions about this medicine, talk to your doctor, pharmacist, or health care provider. Use the Script Save Well Rx pill identifier to quickly and easily identify unknown medicines by imprint*, shape, number, and color. If your pill doesn’t have one, it could be a vitamin, supplement, or foreign drug. DISCLAIMER: This content is provided for informational purposes only. The content is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Patients should always consult their physician with any questions regarding a medical condition and to obtain medical advice and treatment. Do not stop taking this medication without consulting your doctor. Some conditions may become worse when you suddenly stop this drug. Some people who have suddenly stopped taking similar drugs have had chest pain, heart attack, and irregular heartbeat. If your doctor decides you should no longer use this drug, he or she may direct you to gradually decrease your dose over 1 to 2 weeks. When gradually stopping this medication, it is recommended that you temporarily limit physical activity to decrease strain on the heart. Get medical help right away if you develop chest pain/tightness/pressure, chest pain spreading to the jaw/neck/arm, unusual sweating, trouble breathing, or fast/irregular heartbeat. Show More Metoprolol is used with or without other medications to treat high blood pressure (hypertension). Lowering high blood pressure helps prevent strokes, heart attacks, and kidney problems.

    Metoprolol identification

    Metoprolol - DrugBank, Pill Identifier Metoprolol Tartrate - NDC 57664-477 - NDC List

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    • Metoprolol Images and Labels - GoodRx.
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    Identification of intermediates and proposal of degradation pathways. and efficiency of photocatalytic degradation of the β1-blocker metoprolol tartrate MET. Jun 2, 1999. Granulations 1.5 kg, 3000 units were manufactured using a fluid-bed process, lubricated and tablets 100 mg metoprolol tartrate were. Feb 5, 2017. Identification and characterization of photodegradation products of metoprolol in the presence of natural fulvic acid by HPLC-UV-MSn.

     
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