What is amoxicillin clavulanate

Discussion in 'Rx Price Comparison' started by grig-grig, 03-Sep-2019.

  1. Ivan_S_Karpoukh Moderator

    What is amoxicillin clavulanate


    Augmentin (Amoxicillin Trihydrate/Potassium Clavulanate) is classified as an antibiotic medicine and it exhibits a significantly broad spectrum of action against many types of bacteria which can cause infections. Augmentin (Amoxicillin Trihydrate/Potassium Clavulanate) is classified as an antibiotic medicine and it exhibits a significantly broad spectrum of action against many types of bacteria which can cause infections. It is produced from a combination of 2 different ingredients. Axmoxicillin is beta lactam antibiotic which is semi-synthetic, and it is effective against a great deal of both gram negative and gram positive bacterial micro organisms. However, certain types of bacteria which produce beta lactamase enzymes are resistant to it, as they can inactivate amoxicillin. To counter this effect, it is combined with the beta lactamase inhibitor clavulanic acid (in the form of potassium clavulanate). It acts on the beta lacatamse enzymes that occur in the micro-organisms which are resistant to treatment by penicillin or cephalosporin antibiotics. Β-lactamase−producing strains of Haemophilus influenzae and Moraxella catarrhalis Mild to moderate: 500/125 mg PO q12hr or 250/125 mg PO q8hr for 10 days Severe: 875/125 mg PO q12hr or 500/125 mg PO q8hr or 2000 mg (2 extended-release tabs) PO q12hr for 7-10 days Take with meals to avoid GI upset Take suspension at start of meal to enhance absorption Dysphagia: May substitute 250 mg/5 m L suspension for 500/125 mg tablet; may substitute 200 mg/5 m L or 400 mg/5 m L suspension for 875/125 mg tablet Because of the different amoxicillin-to-clavulanate ratios in the 250-mg tablet (amoxicillin 250 mg, clavulanate125 mg) and the 250-mg chewable tablet (amoxicillin 250 mg, clavulanate 62.5 mg), the 250-mg tablet should not be used if the pediatric patient weighs Hypersensitivity reactions Anaphylaxis Anemia Thrombocytopenia Leukopenia Agranulocytosis Hepatoxicity AST/ALT elevation Pseudomembranous colitis Serum sickness Abdominal discomfort Cholestatic jaundice Flatulence Allergy to cephalosporins, carbapenems Different tablets are not interchangeable, because ratios of amoxicillin to clavulanate are different Extended release tablets not for use in renal impairment (Cr Cl Amoxicillin binds to penicillin-binding proteins, thus inhibiting final transpeptidation step of peptidoglycan synthesis in bacterial cell walls; addition of clavulanate inhibits beta-lactamase-producing bacteria, allowing amoxicillin extended spectrum of action It is a semisynthetic antibiotic with a broad spectrum of bactericidal activity, covering both gram-negative and gram-positive microorganisms Not effective against Mycoplasma and Legionella spp Peak plasma time: 2 hr (amoxicillin); 1.1 hr (clavulanic acid) Peak concentration: 8-22 mcg/m L (amoxicillin); 0.8-2.6 mcg/m L (clavulanic acid) AUC: 40-80 mcg•hr/m L (amoxicillin); 2-6 mcg•hr/m L (clavulanic acid) The above information is provided for general informational and educational purposes only. Individual plans may vary and formulary information changes. Contact the applicable plan provider for the most current information.

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    This information sheet explains what amoxicillin + clavulanate does, how to take it and what side effects or problems your child may have when. The combination of amoxicillin and clavulanate is an oral antibiotic widely used in the treatment of mild-to-moderate bacterial infections including sinusitis, bronchitis, otitis media, cellulitis and community acquired pneumonia. Pediatr Infect Dis J. 2003 Aug;228 SupplS139-48. Amoxicillin/clavulanate for infections in infants and children past, present and future. Klein JO1.

    Amoxicillin is used in the treatment of a number of infections, including acute otitis media, streptococcal pharyngitis, pneumonia, skin infections, urinary tract infections, Salmonella infections, Lyme disease, and chlamydia infections. Children with acute otitis media who are younger than 6 months of age are generally treated with amoxicillin or other antibiotic. Although most children with acute otitis media who are older than two years old do not benefit from treatment with amoxicillin or other antibiotic, such treatment may be helpful in children younger than two years old with acute otitis media that is bilateral or accompanied by ear drainage. In the past, amoxicillin was dosed three times daily when used to treat acute otitis media, which resulted in missed doses in routine ambulatory practice. There is now evidence that two times daily dosing or once daily dosing has similar effectiveness. Amoxicillin is recommended as the preferred first-line treatment for community-acquired pneumonia in adults by the National Institute for Health and Care Excellence, either alone (mild to moderate severity disease) or in combination with a macrolide. It is effective as one part of a multi-drug regimen for treatment of stomach infections of Helicobacter pylori. Amoxicillin/clavulanic acid is a combination penicillin-type antibiotic used to treat a wide variety of bacterial infections. Using any antibiotic when it is not needed can cause it to not work for future infections. It will not work for viral infections (such as common cold, flu). Take this medication by mouth with a meal or snack as directed by your doctor. Depending on your specific product, this medication is usually taken every 8 or 12 hours. The dosage is based on your medical condition and response to treatment. For the best effect, take this antibiotic at evenly spaced times. To help you remember, take this medication at the same time(s) every day.

    What is amoxicillin clavulanate

    Augmentin Amoxicillin Trihydrate/Potassium Clavulanate., AMOXICILLIN-CLAVULANATE - Search Livertox Database

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  5. Amoxicillin and amoxicillin-clavulanate have been recommended by guidelines as the drug of choice for bacterial sinusitis and other respiratory infections. Most sinusitis infections are caused by viruses, for which amoxicillin and amoxicillin-clavulanate are ineffective.

    • Amoxicillin - Wikipedia.
    • Amoxicillin/clavulanate for infections in infants and children past..
    • Amoxicillin-clavulanate uses & side-effects PatientsLikeMe.

    Amoxicillin + clavulanate is a combination of two medicines. Amoxicillin is a medicine called an antibiotic. Antibiotics are used to treat certain types of infections caused by germs called bacteria. However, some types of bacteria are able to destroy amoxicillin so that the drug can no longer work. The second medicine, called clavulanate. Chemmart Amoxycillin and Clavulanic Acid 875 mg/125 mg Tablets is a brand of medicine containing the active ingredient Amoxicillin; Clavulanic acid. Find out. Amoxicillin/clavulanic acid is a combination penicillin-type antibiotic used to treat a wide variety of bacterial infections. It works by stopping the growth of.

     
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