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  8. The results of randomized trials suggest that the optimum duration of tamoxifen therapy is at least 5 years. The major benefit, however, is seen in women over 50 years old with ER-positive tumours. In advanced breast cancer, response rates of up to 60% in women with oestrogen receptor (ER)-positive tumours have been reported, In early breast cancer, tamoxifen can produce significant benefits, both statistically and clinically, in terms of reduction in relative risk of relapse or death in all patient subgroups (i.e, ER status, aged 50 years) except premenopausal women with ER-negative tumours. Tamoxifen is currently established as the endocrine treatment of choice in breast cancer. Two large pragmatic trials (a TTom and ATLAS) are under way to determine whether additional benefit can be gained from continuing tamoxifen treatment beyond 5 years. Recent data also suggest possible synergism between tamoxifen and chemotherapy in the treatment of early breast cancer in post-menopausal women. Other benefits of tamoxifen treatment include reduction in the risk of developing contralateral breast cancer. Making Breast Tumors Tamoxifen-Sensitive Cancer Discovery Targeting a Novel ER/HOXB7 Signaling Loop in. - Cancer. Tamoxifen - an overview ScienceDirect Topics
     
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    In this week’s issue of People, former Victoria’s Secret model Jill Goodacre opens up about her five-year battle with breast cancer and the medication she’s been on to keep the disease at bay. Goodacre, who’s married to singer and actor Harry Connick Jr., went through surgery and radiation in 2012 after a tumor was detected via sonogram, and has taken the drug tamoxifen ever since. As she approaches her five-year cancer-free mark, Goodacre says she’s looking forward to stopping tamoxifen. The medication can cause side effects, including weight gain, which Goodacre admits she’s struggled with. “I’ve always been a pretty fit person, and so to be just rounder and heavier and not to really be able to do much about it—that’s been hard,” she told People. “It’s taken a lot out of my self-confidence.” That’s a common problem among breast cancer survivors, says Nikita Shah, MD, medical director of the Cancer Risk Evaluation Program at Orlando Health UF Health Cancer Center. Shah has not treated Goodacre, but does prescribe tamoxifen to many of her own patients.) Still, tamoxifen can be lifesaving, says Dr. Shah, and for many women, its benefits outweigh its potential side effects. New breast cancer treatment guidelines Tamoxifen for 10 years Five More Years Women Face a Difficult Choice on Extending. Breast cancer drugs should be given for 10 years, study. - The Guardian
     
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