Metoprolol and cocaine

Discussion in 'Prescription Pricing' started by SergZorin, 01-Jan-2020.

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    Metoprolol and cocaine


    The following is a hypothetical example of a classic exam question that one might come across as a medical student: A 50-year-old male presents to the emergency department with severe chest pain. His past medical history is significant for congestive heart failure and stent placement. His vitals are significant for a blood pressure of 220/110 and a heart rate of 170. All of the above are acceptable to use in the setting of cocaine-related chest pain If you said D, you would most likely receive full credit, for the classic teaching is that beta-blockers are contraindicated in the setting of chest pain related to cocaine use. On physical exam he appears to be profusely sweating, and his pupils are markedly dilated. Beta-blockers are also frequently withheld from patients with significant heart disease who happen to be active users of cocaine. Troponin I is within normal limits and EKG shows normal sinus rhythm. As medical students we learn not to use beta-blockers in such a setting on many occasions, from test questions like the one above, to mannequin simulations, to interactions with patients on the hospital wards. When prompted, the patient admits to snorting cocaine just a few hours prior to presentation. However, one should question the reasoning behind the practice of not giving beta-blockers to patients who use cocaine. Which of the following should NOT be used in the management of this patient’s symptoms? After all, if as clinicians we choose not to prescribe cocaine users a drug that has a significant mortality benefit in the setting of coronary artery disease [1,2], one might presume that there would be some good evidence to support this practice. Years ago I treated a university student who presented to the emergency department (ED) after drinking several cans of a popular caffeinated energy drink to “pull an all-nighter” during final exam week. He was tremulous, agitated, and pale, with sinus tachycardia ranging from 140 to 160 bpm and normal blood pressure (BP). The house officer (registrar) working with me that night proposed treating him with a benzodiazepine, but I pointed out he had an important exam to take in a few hours and had driven himself to the ED. Rather than snow him with benzos, I suggested metoprolol, a lipophilic beta-1 blocker with both peripheral and central nervous system effects. Her response to this was, “Oh no, you can’t do that – what about unopposed-alpha stimulation? ” I told them I had never experienced or heard of a case of this at our hospital in my 20 plus years of emergency medicine, but I had always been looking for it. ” It was at this point I realized the level of misinformation regarding this dogma had become so pervasive, that newly-minted physicians were applying it as an absolute contraindication to beta-blocker treatment for stimulants. ” She replied, “It’s where you give a beta-blocker and their BP immediately skyrockets.” I asked some other house officers nearby: “It’s when they get an arrhythmia after beta-blockers,” and, “They get chest pain and MI right after beta-blockers, but only with cocaine.” “It puts methamphetamine and cocaine patients at high-risk for aortic and coronary artery dissection.” I then asked, “Have you ever seen it or heard of a case? It was kind of like the emergency medicine equivalent of a snipe hunt. Within minutes his tachycardia resolved, and he felt back to baseline. We watched him for another hour then discharged him.

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    When prompted, the patient admits to snorting cocaine just a few hours prior to. 2 Metoprolol in acute myocardial infarction MIAMI. Jan 11, 2019. Cocaine, purported to be the most potent stimulant of natural origin, is extracted from the leaves of the coca plant Erythroxylum coca, which is. May 24, 2010. Cocaine is an illegal substance used by millions of Americans. for that first dose was intravenous metoprolol in 113 74%, oral metoprolol in.

    Metoprolol belongs to the class of medications called beta-blockers. Metoprolol is used to treat high blood pressure and prevent the symptoms of certain types of angina (chest pain). It is also used to help reduce the risk of death right after a heart attack. Metoprolol is also taken by people who have had a heart attack to reduce the risk of having another one. Metoprolol is often used in combination with other high blood pressure medications such as diuretics (water pills) when the use of one medication by itself is not enough to control blood pressure. This medication may be available under multiple brand names and/or in several different forms. Any specific brand name of this medication may not be available in all of the forms or approved for all of the conditions discussed here. As well, some forms of this medication may not be used for all of the conditions discussed here. What are the potential interactions and history between cocaine and beta blockers? The following provides information about what beta blockers are, and the relationship between cocaine and beta blockers, including interactions and history. Before looking at the interactions and history of cocaine and beta blockers, what are beta blockers? Beta blockers are also referred to as beta-adrenergic blocking agents, and they can treat many different conditions ranging from migraines to high blood pressure. Beta-blockers stop the impact of epinephrine, which is a hormone more commonly known as adrenaline, and in doing so, they reduce blood pressure. When you take a beta blocker, it slows your heartbeat and makes it less forceful, which ultimately lowers blood pressure. When you take beta blockers, it also helps improve blood flow by opening vessels.

    Metoprolol and cocaine

    A Review of Beta-blockers in the Setting of Cocaine Associated., Cocaine Acute intoxication - UpToDate

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  5. Cocaine abuse remains a significant worldwide health problem. Patients with cardiovascular toxicity from cocaine abuse frequently present to the emergency.

    • Blockers, Cocaine, and the Unopposed α-Stimulation Phenomenon..
    • Blockers for Chest Pain Associated With Recent Cocaine Use..
    • Metoprolol Davis's Drug Guide.

    A lipophilic beta-blocker, metoprolol, was used to definitively treat agitation and tachycardia in a cocaine-toxic patient. It was later discovered. The evaluation and management of patients who have chest pain or myocardial infarction after using cocaine should mirror that of patients who have not used. Drug monographs for METOPROLOL-HYDROCHLOROTHIAZIDE provide an. In addition, cocaine can reduce the therapeutic effects of beta-blockers. Major.

     
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