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Deadly overdoses, both intentional and accidental, have actually been reported in children and also adults that have actually consumed Colchicine [See Overdosage (10)] Colchicine pills must be kept out of the reach of children. Considering that Colchicine is a substrate for both the CYP3A4 metabolizing enzyme as well as the P-glycoprotein efflux transporter, inhibition of either of these paths might lead to Colchicine-related poisoning. Restraint of both CYP3A4 and P-gp by twin inhibitors such as clarithromycin has actually been reported to create life-threatening or fatal Colchicine poisoning as a result of considerable increases in systemic Colchicine levels. Consequently, concomitant use of Colchicine capsules and also inhibitors of CYP3A4 or P-glycoprotein need to be stayed clear of [ See Drug Interactions (7)] Minimized daily dose must be taken into consideration and the individual needs to be kept an eye on carefully for Colchicine poisoning if evasion is not possible. 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