Prednisone interaction

Discussion in 'Prescription Drug Assistance' started by vadkuz, 21-Dec-2019.

  1. marsez Moderator

    Prednisone interaction


    The dose of a drug and dosage of the drug are two different terminologies. Dose is defined as the quantity or amount of medicine given by the doctor or taken by the patient at a given period. Dosage is the regimen prescribed by the doctor about how many days and how many times per day the drug is to be taken in specified dose by the patient. The dose is expressed in mg for tablets or gm, micro gm sometimes, ml for syrups or drops for kids syrups. The dose is not fixed for a drug for all conditions, and it changes according to the condition or a disease. Dosage of Prednisone should be individualized according to the severity of the disease and the response of the patient. For pediatric patients, the recommended dosage should be governed by the same considerations rather than strict adherence to the ratio indicated by age or body weight. The maximal activity of the adrenal cortex is between 2 am and 8 am and is minimal between 4 pm and midnight. Though prednisone can offer health benefits when used as directed to treat medical problems, when combined with alcohol, a person may be at risk of experiencing serious health risks. The two, used in combination, can weaken a person’s immune system, put them at a greater risk for osteoporosis and contribute to other health problems. Individuals who are taking prednisone long-term for chronic conditions may experience more risks and dangers from this combination. However, any person who is taking this medication and is considering drinking, even in moderate amounts, should speak to their doctor prior to consuming alcohol. Even sporadic episodes of alcohol abuse, like binge drinking, could potentially cause problems for a person who is taking prednisone. Prednisone is a steroid medication, or corticosteroid, that comes in a tablet, liquid solution or concentrated oral solution. Brand names of prednisone include, but are not limited to, Prednisone Intensol, Sterapred and Sterapred DS.

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    Find patient medical information for Prednisone Oral on WebMD including its uses, side effects and safety, interactions, pictures, warnings and user ratings. There are 23 disease interactions with prednisone which include + Tuberculin Test. Electrolyte Imbalance. Gi Perforation. Infections. Mi. Ocular Herpes Simplex. Pud. Prednisone is a glucocorticoid medication mostly used to suppress the immune system and decrease inflammation in conditions such as asthma, COPD, and rheumatologic diseases. It is also used to treat high blood calcium due to cancer and along with other steroids for adrenal insufficiency.

    Соединения такого рода более активны, чем естественные, природные вещества. Влияние данной группы веществ на водно-соленой обмен в организме сводится к минимуму, побочные реакции проявляются редко. Противовоспалительное, глюкокортикостероидное, противоаллергическое. Вещество способствует процессам стабилизации обусловлены повышением реакции организма на сосудосужающее вещества, стимулированием деятельности сердечно-сосудистой системы и задержкой в тканях воды и натрия. Вещество стимулирует работу центральной нервной системы, Также благодаря синтетическому и ядовитых веществ из печени, снижается проницаемость мембран клеток. После перорального приема вещество усваивается обычным способом. Максимальной своей концентрации, достигая в течение 60-120 минут. Преднизон обладает высокой биологической доступностью, порядка 90%. Фармакокинетические параметры средства имеют линейную зависимость от дозировки. Препараты Преднизона назначают: Дозировка и режим приема индивидуальные. В качестве поддерживающей дозы используют по 5-10 мг. В случае необходимости начальная дозировка может равняться 100 мг, поддерживающая до 15 мг. Day 1: 10 mg PO before breakfast, 5 mg after lunch and after dinner, and 10 mg at bedtime Day 2: 5 mg PO before breakfast, after lunch, and after dinner and 10 mg at bedtime Day 3: 5 mg PO before breakfast, after lunch, after dinner, and at bedtime Day 4: 5 mg PO before breakfast, after lunch, and at bedtime Day 5: 5 mg PO before breakfast and at bedtime Day 6: 5 mg PO before breakfast Immediate-release: ≤10 mg/day PO added to disease-modifying antirheumatic drugs (DMARDs) Delayed-release: 5 mg/day PO initially; maintenance: lowest dosage that maintains clinical response; may be taken at bedtime to decrease morning stiffness with rheumatoid arthritis Take with meal or snack High-dose glucocorticoids may cause insomnia; immediate-release formulation is typically administered in morning to coincide with circadian rhythm Delayed-release formulation takes about 4 hours to release active substances; thus, with this formulation, timing of dose should take into account delayed-release pharmacokinetics and disease or condition being treated (eg, may be taken at bedtime to decrease morning stiffness with rheumatoid arthritis) Allergic: Anaphylaxis, angioedema Cardiovascular: Bradycardia, cardiac arrest, cardiac arrhythmias, cardiac enlargement, circulatory collapse, congestive heart failure, fat embolism, hypertension, hypertrophic cardiomyopathy in premature infants, myocardial rupture after recent myocardial infarction, pulmonary edema, syncope, tachycardia, thromboembolism, thrombophlebitis, vasculitis Dermatologic: Acne, allergic dermatitis, cutaneous and subcutaneous atrophy, dry scalp, edema, facial erythema, hyper- or hypopigmentation, impaired wound healing, increased sweating, petechiae and ecchymoses, rash, sterile abscess, striae, suppressed reactions to skin tests, thin fragile skin, thinning scalp hair, urticaria Endocrine: Abnormal fat deposits, decreased carbohydrate tolerance, development of cushingoid state, hirsutism, manifestations of latent diabetes mellitus and increased requirements for insulin or oral hypoglycemic agents in diabetics, menstrual irregularities, moon facies, secondary adrenocortical and pituitary unresponsiveness (particularly in times of stress, as in trauma, surgery, or illness), suppression of growth in children Fluid and electrolyte disturbances: Fluid retention, potassium loss, hypertension, hypokalemic alkalosis, sodium retention Gastrointestinal: Abdominal distention, elevation of serum liver enzymes levels (usually reversible upon discontinuance), hepatomegaly, hiccups, malaise, nausea, pancreatitis, peptic ulcer with possible perforation and hemorrhage, ulcerative esophagitis General: Increased appetite and weight gain Metabolic: Negative nitrogen balance due to protein catabolism Musculoskeletal: Osteonecrosis of femoral and humeral heads, Charcot-like arthropathy, loss of muscle mass, muscle weakness, osteoporosis, pathologic fracture of long bones, steroid myopathy, tendon rupture, vertebral compression fractures Neurologic: Arachnoiditis, convulsions, depression, emotional instability, euphoria, headache, increased intracranial pressure with papilledema (pseudotumor cerebri; usually following discontinuance of treatment), insomnia, meningitis, mood swings, neuritis, neuropathy, paraparesis/paraplegia, paresthesia, personality changes, sensory disturbances, vertigo Ophthalmic: Exophthalmos, glaucoma, increased intraocular pressure, posterior subcapsular cataracts, central serous chorioretinopathy Reproductive: Alteration in motility and number of spermatozoa Untreated serious infections Documented hypersensitivity Varicella Administration of live or attenuated live vaccine (Advisory Committee on Immunization Practices (ACIP) and American Academy of Family Physicians (AAFP) state that administration of live virus vaccines usually is not contraindicated in patients receiving corticosteroid therapy as short-term ( Monitor for hypothalamic-pituitary-adrenal (HPA) axis suppression, Cushing syndrome, and hyperglycemia Prolonged use associated with increased risk of infection; monitor Use with caution in cirrhosis, ocular herpes simplex, hypertension, diverticulitis, hypothyroidism, myasthenia gravis, peptic ulcer disease, osteoporosis, ulcerative colitis, psychotic tendencies, renal insufficiency, pregnancy, diabetes mellitus, congestive heart failure, thromboembolic disorders, GI disorders Long-term treatment associated with increased risk of osteoporosis, myopathy, delayed wound healing Patients receiving corticosteroids should avoid chickenpox or measles-infected persons if unvaccinated Latent tuberculosis may be reactivated (patients with positive tuberculin test should be monitored) Some suggestion (not fully substantiated) of slightly increased cleft palate risk if corticosteroids are used in pregnancy Methylprednisolone is preferred in hepatic impairment because prednisone must be converted to prednisolone in liver Prolonged corticosteroid use may result in elevated intraocular pressure, glaucoma, or cataracts May cause impairment of mineralocorticoid secretion; administer mineralocorticoid concomitantly May cause psychiatric disturbances; monitor for behavioral and mood changes; may exacerbate pre-existing psychiatric conditions Monitor for Kaposi sarcoma Pregnancy category: C (immediate release); D (delayed release) Drug may cause fetal harm and decreased birth weight; maternal corticosteroid use during first trimester increases incidence of cleft lip with or without cleft palate Lactation: Of maternal serum metabolites, 5-25% are found in breast milk; not recommended, or, if benefit outweighs risk, use lowest dose Glucocorticosteroid; elicits mild mineralocorticoid activity and moderate anti-inflammatory effects; controls or prevents inflammation by controlling rate of protein synthesis, suppressing migration of polymorphonuclear leukocytes (PMNs) and fibroblasts, reversing capillary permeability, and stabilizing lysosomes at cellular level; in physiologic doses, corticosteroids are administered to replace deficient endogenous hormones; in larger (pharmacologic) doses, they decrease inflammation The above information is provided for general informational and educational purposes only. Individual plans may vary and formulary information changes. Contact the applicable plan provider for the most current information.

    Prednisone interaction

    Prednisone – Side Effects, Dosage, Interactions – Drugs, Drug Interactions -

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  7. It is often recommended to avoid drinking alcohol while taking prednisone to avoid exacerbation of prednisone side effects. Though additional studies may need to be done to show their interactions, alcohol alone is a health risk and is best to avoid especially if a medical condition is present.

    • Prednisone interactions - MedHelp.
    • Prednisone - Wikipedia.
    • Prednisone Oral Route Before Using - Mayo Clinic.

    Prednisone is not known to interact with foods, but if you drink alcohol when taking this steroid medicine over a long period of time, it could raise your risk of stomach ulcers and bleeding in the digestive tract. Medscape - Anti-inflammatory-specific dosing for Prednisone Intensol prednisone, frequency-based adverse effects, comprehensive interactions, contraindications, pregnancy & lactation schedules. Prednisone can decrease the level of potassium in your blood. Taking prednisone with certain diuretics can increase this risk. If you are taking these medicines together, your healthcare provider should monitor your potassium levels and may prescribe a potassium supplement if necessary.

     
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