Viagra development

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  1. evg_pits New Member

    Viagra development


    The process development and scale-up of the sildenafil citrate process is reviewed. Key environmental metrics are reported at several time points during the development process. Significant achievements during the development of recovery early in the product's commercial lifetime. The result of this work is that the E-factor for the process is very low with just 6 Kg of waste per kilogram of product compared with an industry average of 25–100 Kg. Pfizer received the 2003 UK Award for Green Chemical Technology (Best Process category) for the sildenafil citrate process. was approved for prescription use within the United States, the European Union and Japan during 1998 and immediately became a major seller, achieving sales of more than $1 billion during its first year on the market. With such a rapid sales take off it was critical that the environmental performance of the synthesis was good from the outset. For example, typical syntheses involve complex molecules with demanding quality standards, often requiring batch processing; there are greater regulatory constraints and in general high value, low volume products are being made. Dr Wheate in the past has received funding from the ACT Cancer Council, Tenovus Scotland, Medical Research Scotland, Scottish Crucible and the Scottish Universities Life Sciences Alliance for research into platinum drugs. Dr Wheate is a named inventor on two international patents dealing with the drug delivery of anticancer drugs. Viagra is one brand name of a drug that is used to treat erectile dysfunction (impotence): the inability to get, and maintain, an erection. It is also used in the treatment of high blood pressure specific to the heart and the arteries that feed the lungs. The generic name of the drug is sildenafil (pronounced sill-den-a-fill). Like many great scientific discoveries, the benefits of Viagra in treating erectile dysfunction were discovered by accident. The pharmaceutical company Pfizer initially developed the drug in 1989 as a treatment for high blood pressure and angina.

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    The development of an environmentally benign synthesis of sildenafil citrate Viagra™ and its assessment by Green Chemistry metrics†. Nov 13, 2018. Viagra sildenafil, Pfizer's blockbuster drug for erectile dysfunction, is a classic example of how a drug developed for one thing can turn out to. Sildenafil Viagra and its metabolite UK-103,320 using automated. The development of the ASTED automated sequential trace enrichment of dialysates.

    The researchers behind the breakthrough now say that they plan to test the mediation on humans, but warn it could be another 10 years before the product is on the market. The team, at Albert Einstein College of Medicine of Yeshiva University, New York, said that other attempts at administering drugs through the skin had not been very successful. Davies, associate professor of urology and one of the co-authors of the study, added: "The response time to the nanoparticles was very short, just a few minutes, which is basically what people want in an Erectile Dysfunction medication. "In both rats and humans, it can take 30 minutes to one hour for oral ED medications to take effect." The findings were published online in the Journal of Sexual Medicine. Ten years ago this month, the Food and Drug Administration's approval of a little blue pill changed the sex lives of millions of men and women. Viagra, the first oral treatment for erectile dysfunction was developed accidentally by scientists at Pfizer Laboratories and was greenlighted for use by the FDA on March 27, 1998."Originally, we were testing sildenafil, the active drug in Viagra, as a cardiovascular drug and for its ability to lower blood pressure,'' Dr. Brian Klee, senior medical director at Pfizer, told French news agency, AFP. "But one thing that was found during those trials is that people didn't want to give the medication back because of the side effect of having erections that were harder, firmer and lasted longer.'' Since its approval, Viagra has been used by 35 million men around the world. It took the taboo out of impotence — former presidential candidate Bob Dole who suffered from erectile dysfunction after surgery for prostate cancer once appeared in a commercial for the drug — and made it easier to treat.

    Viagra development

    From Velcro to Viagra 10 products that were invented. - History Extra, Viagra and Cialis PDE-5 Inhibitors May Have Broader Applications in.

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    Viagra is described by some as a “lifestyle” drug, supposedly distinguishable. for the Development of Pharmacological Therapies for Erectile Dysfunction,” in. These results argue against the loss of tolerability or the development of. the US Food and Drug Administration FDA approved sildenafil citrate Viagra®. WASHINGTON -- The German pharmaceutical company Boehringer Ingelheim announced it is halting development of flibanserin Girosa.

     
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