Tamoxifen and stroke

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  1. MoneyLover XenForo Moderator

    Tamoxifen and stroke


    Tamoxifen blocks the actions of estrogen, a female hormone. Certain types of breast cancer require estrogen to grow. Tamoxifen is used to treat some types of breast cancer in men and women. Tamoxifen is also used to lower a woman's chance of developing breast cancer if she has a high risk (such as a family history of breast cancer). Tamoxifen may also be used for purposes not listed in this medication guide. Hormonal contraception (such as birth control pills, injections, implants, skin patches, and vaginal rings) may not be effective enough to prevent pregnancy while taking tamoxifen. Ask your doctor about using non hormonal birth control (condom, diaphragm with spermicide, or intrauterine device/IUD). Patients who take a commonly prescribed breast cancer drug, Tamoxifen (learn more about Tamoxifen here) are at an increased risk of developing blood clots. Researchers have discovered that this risk is much greater (500% higher) in some patients with a specific genetic mutation, called “Factor 5 Leiden” or FVL mutation. In my opinion, any patient who is on Tamoxifen and who is already at a high risk of blood clots (see the list of risk factors, below) should be offered this test. If you carry this mutation, you may be offered alternative medications (i.e. aromatase inhibitors) with no increased risk of blood clots.

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    Whether tamoxifen increases the risk of a stroke has been unclear; a couple of studies have found a reduced risk and several found an increased risk. stroke risk posed by tamoxifen. To determine the stroke risk posed by tamoxifen, Duke University researchers pooled findings from nine clinical trials involving about 40,000 breast cancer patients. Studies that looked as solid as this week's tamoxifen study assured. the risk of pulmonary embolism, DVT, stroke and endometrial cancer. But chemotherapy does in breast cancer patients, study finds.

    The use of aromatase inhibitors, hormone-therapy drugs used to treat patients with breast cancer, was not associated with an increased risk of fatal cardiovascular events, including heart attacks or stroke, compared with tamoxifen, another commonly prescribed anti-cancer drug that works on hormones and which has been associated with a serious risk of stroke, report investigators. In a new study from Kaiser Permanente, researchers found the use of aromatase inhibitors, hormone-therapy drugs used to treat patients with breast cancer, was not associated with an increased risk of fatal cardiovascular events, including heart attacks or stroke, compared with tamoxifen, another commonly prescribed anti-cancer drug that works on hormones and which has been associated with a serious risk of stroke. , found that those who only used aromatase inhibitors or used the drugs after tamoxifen treatment had a 26 to 29 percent higher risk of less serious cardiovascular events, such as abnormal heart beat and pericarditis (a swelling and irritation of the thin membrane surrounding the heart), compared with those who only used tamoxifen. Cardiovascular disease is a leading cause of death in older breast cancer survivors. Although aromatase inhibitors are considered superior in reducing risk of cancer recurrence compared to tamoxifen in postmenopausal women with hormone receptor positive breast cancer, previous studies have provided inconclusive or mixed results on the potential cardiovascular risk associated with aromatase inhibitors. "Our study is a comprehensive assessment of the impact aromatase inhibitors have on cardiovascular risk and provides reassurance that the hormone therapy to reduce breast cancer recurrence does not increase risk of the most fatal cardiovascular events," noted Reina Haque, Ph D, MPH, research scientist, Kaiser Permanente Southern California Department of Research & Evaluation. "A particular strength of our study is that we accounted for women's other potential cardiovascular risk factors as well as medication used to treat high blood pressure and high cholesterol." Estrogen and progesterone are hormones produced by women that can promote the growth of some breast cancers. Tamoxifen (Nolvadex®) is a medication in pill form that has been used for more than 25 years to treat breast cancer in women and men. Tamoxifen is one of the most common endocrine therapy drugs. It has been shown to decrease the chance of recurrence in some early-stage breast cancers and to prevent the development of cancer in the opposite breast. Tamoxifen can also slow or stop the growth of cancer cells present in the body. There are an estimated 29 million women at increased risk for breast cancer in this country, and tamoxifen may offer another alternative to watchful waiting or prophylactic (preventative) mastectomy. Tamoxifen is classified as a selective estrogen receptor modulator (SERM) and works as an anti-estrogen: While the hormone estrogen promotes the growth of breast cancer cells, tamoxifen works by blocking estrogen from attaching to estrogen receptors on these cells. By blocking the estrogen receptors, it is believed that the growth of the breast cancer cells will be halted.

    Tamoxifen and stroke

    Tamoxifen MedlinePlus Drug Information, Why Women Are Not Flocking to Tamoxifen Center for Health.

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  4. To assess the overall risk of stroke, specifically ischemic stroke, associated with tamoxifen use by performing a meta-analysis of data reported in breast cancer.

    • Risk of ischemic stroke with tamoxifen treatment for breast cancer A..
    • Tamoxifen Doesn't Increase Stroke Risk - Consumer HealthDay.
    • Coronary Heart Disease and Stroke with Aromatase Inhibitor..

    Oct 17, 2017. Bushnell, C. D. and Goldstein, L. B. 2004. Risk of ischemic stroke with tamoxifen treatment for breast cancer a meta-analysis. Neurology 63. Clinical decision-making about tamoxifen use for breast cancer treatment need not include heightened concern about stroke,” Dr. Geiger said. Jan 30, 2015. “Tamoxifen is very good at preventing breast cancer, but it also has to be weighed against an increased risk of uterine cancer, stroke, or blood.

     
  5. alaherus New Member

    ERYTHROMYCIN (er ith roe MYE sin) is a macrolide antibiotic. It is used to treat certain kinds of bacterial infections. It will not work for colds, flu, or other viral infections. This medicine may be used for other purposes; ask your health care provider or pharmacist if you have questions. You can take this medicine on an empty stomach or with food or milk. Do not take your medicine more often than directed. COMMON BRAND NAME(S): E-Mycin, Ery-Tab, ERYC, PCE, PCE Dispertab They need to know if you have any of these conditions: Take this medicine by mouth with glass of water. Finish the full course prescribed by your doctor even if you think your condition is better. If it is almost time for your next dose, take only that dose. Do not take this medicine with any of the following medications: This list may not describe all possible interactions. Do not stop taking except on your doctor's advice. Give your health care provider a list of all the medicines, herbs, non-prescription drugs, or dietary supplements you use. Talk to your pediatrician regarding the use of this medicine in children. Overdosage: If you think you have taken too much of this medicine contact a poison control center or emergency room at once. Also tell them if you smoke, drink alcohol, or use illegal drugs. Tell your doctor or health care professional if your symptoms do not improve or if they get worse. Buy Erythromycin Online, 250mg Tablets - UK Pharmacy - Buy Erythromycin Trusted Drugstore No Prescription Erythromycin tablets or capsules, delayed release Cleveland Clinic
     
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