WARNING: SUICIDALITY AND ANTIDEPRESSANT DRUGS ZOLOFT and other antidepressant medicines may increase suicidal thoughts or actions in some people 24 years of age and younger, especially within the first few months of treatment or when the dose is changed. Watch for these changes and call your healthcare provider right away if you notice new or sudden changes in mood, behavior, actions, thoughts, or feelings, especially if severe. Pay particular attention to such changes when ZOLOFT is started or when the dose is changed. Depression or other serious mental illnesses are the most important causes of suicidal thoughts or actions. Watch for these changes and call your healthcare provider right away if you notice new or sudden changes in mood, behavior, actions, thoughts, or feelings, especially if severe. Keep all follow-up visits with your healthcare provider and call between visits if you are worried about symptoms. Before taking ZOLOFT, tell your doctor and pharmacist about all prescription and over-the-counter medications and supplements you take or plan to take including: those to treat migraines, psychiatric disorders (including other antidepressants or amphetamines) to avoid a potentially life-threatening condition called serotonin syndrome; aspirin, other NSAID pain relievers, or other blood thinners because they may increase the risk of bleeding. Two of the most frequently prescribed medications don’t go well together, Stanford researchers have learned. The unfortunate result: Some patients experience more pain and are possibly more prone to opioid abuse. The medications are hydrocodone, an opioid often given to patients after surgery and one of the most prescribed medications in the United States, and selective serotonin reuptake inhibitors (SSRIs), a common type of psychiatric medication that includes Prozac and Zoloft. A team of Stanford scientists suspected that these two types of drugs wouldn’t get along. Hydrocodone needs a liver enzyme to convert it into a form that relieves pain. To test their hunch, the researchers examined electronic health records of 4,306 depressed patients who had surgery at Stanford Health Care. In a study in , they showed that the patients on SSRIs who’d been given hydrocodone — or other opioids that require conversion by the liver — experienced higher pain levels after surgery. Prescribing these patients non-opioids or opioids that don’t need conversion — such as morphine, fentanyl or oxycodone — may help reduce opioid abuse, the researchers suggested. 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