Fluoroquinolone use is associated with the development of tendinopathy, most commonly affecting the Achilles tendon. Here we present the first reported case of bilateral iliopsoas tendon rupture associated with prolonged ciprofloxacin use. This older woman presented with non-traumatic, sudden onset hip pain which was diagnosed as a right iliopsoas rupture on MRI. Despite stopping ciprofloxacin, she went on to develop rupture of the contralateral iliopsoas tendon. This case highlights the time lag between fluoroquinolone use and susceptibility to this rare but important complication. A 70-year-old woman presented with sudden onset, severe pain in her right groin on standing from a chair. She normally mobilised with a crutch and described several months of gradually worsening hip pain but no history of trauma. [Posted 12/20/2018]AUDIENCE: Health Professional, Infectious Disease, Cardiology, Patient ISSUE: FDA review found that fluoroquinolone antibiotics can increase the occurrence of rare but serious events of ruptures or tears in the main artery of the body, called the aorta. These tears, called aortic dissections, or ruptures of an aortic aneurysm can lead to dangerous bleeding or even death. They can occur with fluoroquinolones for systemic use given by mouth or through an injection. BACKGROUND: Fluoroquinolone antibiotics are approved to treat certain bacterial infections and have been used for more than 30 years. They work by killing or stopping the growth of bacteria that can cause illness. Without treatment, some infections can spread and lead to serious health problems (see List of Currently Available FDA-Approved Systemic Fluoroquinolones, available at RECOMMENDATION: Healthcare professionals should: Taking ciprofloxacin increases the risk that you will develop tendinitis (swelling of a fibrous tissue that connects a bone to a muscle) or have a tendon rupture (tearing of a fibrous tissue that connects a bone to a muscle) during your treatment or for up to several months afterward. Sildenafil soft tabs Cialis from australia Findings suggest that ciprofloxacin and other antibiotics of the same class should be. tissue, including tendon rupture, tendonitis and retinal detachment. Ciprofloxacin increases risk of tears and rupture in mouse aortas. Gareth Gillespie and Sarah Baggot highlight the risk of tendon ruptures as a complication of ciprofloxacin. The antibiotic ciprofloxacin is widely used in. Objectives Fluoroquinolone-associated tendon ruptures are a recognised. setting included ciprofloxacin, norfloxacin, levofloxacin, moxifloxacin, and ofloxacin. Gareth Gillespie and Sarah Baggot highlight the risk of tendon ruptures as a complication of ciprofloxacin The antibiotic ciprofloxacin is widely used in Singapore and Hong Kong – but while its uses are well-known, a rare but well-established complication, tendon rupture, is less so. MPS has recently handled a number of cases in Singapore where a patient has suffered tendon rupture after taking ciprofloxacin, yet the prescribing doctor was unaware of this complication. Our aim is not so much to influence clinical judgment about appropriate antibiotic use but to increase awareness, so that doctors and patients are better informed during the consent process. The complication, although not very common, is more widely known in countries such as the United Kingdom and the United States; this article explores the available literature to highlight the complication’s symptoms and signs, patient risk factors, and the likelihood of it occurring. Ciprofloxacin is part of a group of fluoroquinolone antibiotics and is used to treat respiratory, urinary tract, gastrointestinal and abdominal infections. Fluoroquinolone-associated tendinopathy was first reported in 1983, when a 56-year-old renal transplant patient who was taking norfloxacin for a urinary tract infection with septicemia, developed Achilles tendinopathy. Although norfloxacin, ofloxacin, pfloxacin and levofloxacin have been linked to tendon injuries, a study published in 2000 concluded that ciprofloxacin was the most common fluoroquinolone in such cases, appearing in 90% of them. UPDATE: A few months after this article was posted, the work by Baylor researchers has begun to have international impact. The use of ciprofloxacin and other antibiotics of the class of fluoroquinolones may be associated with disruption of the normal functions of connective tissue, including tendon rupture, tendonitis and retinal detachment. These observations reported in a number of journals resulted in the drugs currently having a black box warning physicians and patients of the potential deleterious side effects. The endothelium, the thin layer of cells that line our arteries and veins, is like a gatekeeper, controlling the movement of materials into and out of the bloodstream. Endothelial cells are held tightly together by specialized proteins that function like strong ropes (red) and others that act like cement (blue). NIH Image Gallery “A natural tissue to worry about is the aorta, a blood vessel that relies heavily on having a sound connective tissue component – called the extracellular matrix – to maintain its integrity,” said first author Dr. Le Maire, director of research in the division of cardiothoracic surgery, vice-chair for research and professor of surgery and of molecular physiology and biophysics at Baylor College of Medicine. Two retrospective clinical studies looked at the possible association between fluoroquinolones and cardiovascular problems. “They found that patients who received fluoroquinolones had a higher risk for aneurysms (formation of balloon-like areas in the aorta that weaken the integrity of the vessel), ruptures or dissections (tears in the wall) than patients who did not receive the antibiotics. Ciprofloxacin tendon rupture Got Cipro? If You Exercise, Be Careful! - The Doctor Weighs In, Complications from ciprofloxacin - Medical Protection Society Prednisone 5 mg daily July 8, 2008 -- Federal regulators are ordering new warnings on Cipro and similar antibioticsbecause of increased risk oftendinitis and tendon. FDA Warns That Cipro and Similar Antibiotics May Rupture Tendons. Fluoroquinolones and collagen associated severe adverse events a.. Ciprofloxacin MedlinePlus Drug Information. As ciprofloxacin and other fluoroquinolones are prescribed more frequently. In these cases, the only option is to treat the tendinopathy or tendon rupture in the. May 17, 2017. The Cipro injury case attorneys at the Drug Law Center are currently. 2008 that taking these drugs could cause tendinitis and tendon rupture. Key Words adverse effects, tendinitis, tendon rupture. Commonly used fluoroquinolones include ciprofloxacin, levofloxacin, pefloxacin, and norfloxacin.