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    This site uses cookies to improve your experience and to provide services and advertising. By continuing to browse, you agree to the use of cookies described in our Cookies Policy. You may change your settings at any time but this may impact on the functionality of the site. STOCKS OF ONE of the most widely prescribed antibiotics in primary care may soon run out and be unavailable in Ireland until late next year. The Irish Pharmacy Union (IPU) says that it is ‘serious concerned’ by impending shortages of Augmentin and the potential effect it could have on patient care. The Glaxo Smith Kline manufactured antibiotic is used in adults and children to treat a raft of different infections including severe ear, nose and throat infections like bronchitis and pneumonia. Augmentin is also used to prevent infections associated with major surgical procedures. The problem is worsened because supplies of generic equivalents of the drug are also expected to be affected due to problems in the supply from Glaxo Smith Kline. The phrase allergic to penicillin is commonly seen in medical notes and on medicine charts. The diagnosis of penicillin allergy is often simply accepted without obtaining a detailed history of the reaction. It has been reported that a significant percentage of patients labelled as penicillin allergic are not truly allergic to the drug. As a result, penicillins are unnecessarily withheld from these patients, which may subsequently affect their clinical outcomes. rashes) to penicillin occur in between 1 and 10% of exposed patients but true anaphylactic reactions (which can be fatal) occur in less than 0.05% of treated patients. Please note that patients who have a vague history of symptoms or gastro-intestinal intolerance are probably not truly allergic to penicillins. vancomycin) are all unrelated to penicillins and are safe to use in the penicillin allergic patient.lways identify and document the nature of the reported allergy and drug name on the medicine chart and in the medical notes. ndividuals with a history of Type I allergy clinically recognisable by features of urticaria, laryngeal oedema, bronchospasm, hypotension or local swelling within 72 hours of administration, or development of a pruritic rash (even after 72 hours) should NOT receive a penicillin. The prescriber has the primary responsibility for ensuring that the allergy/sensitivity details are completed on all relevant medicine charts and medical notes. Clinical studies suggest that the incidence of cross-reactivity to cephalosporins in penicillin-allergic patients is around 10% but this is thought to be an overestimate.

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    Since the accidental discovery of penicillin in 1929 by Alexander Fleming, antibiotic use has saved countless lives. Unfortunately, antibiotics are losing their effectiveness. Today, modern medicine faces the challenge of antibiotic resistance, thanks to the overuse of antibiotic medication. One example is methicillin-resistant Staphylococcus aureus (MRSA), which now accounts for approximately 20% of serious infections in some areas of the United States. MRSA is also now becoming resistant to vancomycin, the choice medication for this serious problem. Interestingly though, back in the 1930s, Fleming lectured throughout the world, warning that less than judicious use of these drugs could lead to problems. He cautioned us not to give penicillin unless there was a clear need for it. Fleming noted in his early experimentation clear evidence of bacteria’s ability to get around antibiotic exposure. Beta-lactam antibiotics include penicillins, cephalosporins and related compounds. As a group, these drugs are active against many gram-positive, gram-negative and anaerobic organisms. Information based on “expert opinion” and antimicrobial susceptibility testing supports certain antibiotic choices for the treatment of common infections, but less evidence-based literature is available to guide treatment decisions. Evidence in the literature supports the selection of amoxicillin as first-line antibiotic therapy for acute otitis media. Alternative drugs, such as amoxicillin-clavulanate, trimethoprim-sulfamethoxazole and cefuroxime axetil, can be used to treat resistant infections. Penicillin V remains the drug of choice for the treatment of pharyngitis caused by group A streptococci. Inexpensive narrow-spectrum drugs such as amoxicillin or trimethoprim-sulfamethoxazole are first-line therapy for sinusitis.

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