Belsomra (suvorexant) is a unique drug that alters the signaling of neurotransmitters called orexins. Orexins are responsible for regulating the sleep wake cycle and are thought to promote wakefulness. Belsomra acts to block orexins to help individuals fall asleep and sleep for longer periods of time. Belsomra should be taken 30 minutes prior to going to bed on an empty stomach. You should not take Belsomra if you have less than seven hours remaining before your desired wake time. You should take the lowest effective dose of Belsomra as taking higher than needed doses can result in an increased risk of side effects which include, but are not limited to: Data indicates that Belsomra has similar efficacy to Ambien but is associated with the rare side effect of transient leg weakness. In addition, Belsomra may have more potential for drug interactions due to how it affects the metabolizing enzyme CYP3A4. This means that Belsomra may help alleviate insomnia without compromising sleep architecture. I think it’s going to take a few more years of clinical experience to see how Belsomra stacks up against the other sleep aids. When comparing Belsomra vs Ambien, it is important to recognize that Belsomra has this important advantage: it is a more selective agent with a more favorable side effect profile and is not a substance of abuse. I just tried Belsomra for the first time getting the 20mg 10 free pill trial after my doctor was very hesitant to write the script because she said it has not been on the market long and the side effects are worse then Ambien. I’ve heard that as well – that some people have terrible reactions to Belsomra. I have been on Ambien a long time and if not abused with alcohol the drug is very safe and works very good as long as you don’t eat a large meal and then try to go to bed. Belsomra is unlikely to result in the same kind of withdrawal syndrome you might get from prolonged Ambien dependence. What Belsomra did to me last night was a 8 hour nightmare, I never went to sleep, SO IT DOES NOT WORK at least for me. Rapid withdrawal from chronic, high-dose Ambien use can result in seizures, for example. It made me dizzy and gave me severe anxiety and scary horrible thoughts went through my mind all night long. I took a Ambien after waiting 8 hours for this drug to wear off and still I was not able to go to sleep so I now have been up over 40 hours and not one bit tired as I type this. I had severe dry mouth but I get this with most meds. Lunesta at least worked a little but the horrible metal bitter taste is not worth ever taking another Lunesta ever again. Cipro colitis Doxycycline 50 mg bid Compare Belsomra vs. Lunesta, which is better for uses like Insomnia. Compare head-to-head ratings, side effects, warnings, dosages, interactions and patient reviews. Patients rated Belsomra and Lunesta evenly with 2.8/5. Clinical testing has shown that this new drug is no more effective than existing drugs, like Lunesta and Ambien. are less worried. "Nothing happened in the trials that made Belsomra. Ambien. Ambien is also known by its generic name, zolpidem tartrate. Unlike Belsomra, a generic for Ambien is available on the market. Ambien works by interacting with GABA A receptors to increase inhibitory effects in the brain and ultimately, induce sleep. Ambien is available as a 5 mg or 10 mg oral tablet. Belsomra and Ambien are two brand name drugs indicated to treat insomnia. While both drugs are able to treat the disorder, they are chemically different with different mechanisms of action. Belsomra works by interacting with orexin receptors while Ambien exerts its effects on GABA A receptors. Both drugs are metabolized similarly and dosed at bedtime. However, there are some differences to note between the two. Belsomra is also known by its chemical or generic name, suvorexant. There is no generic drug available which means Belsomra may be pricier than other insomnia medications. Since the beginning of the 90s, the majority of sleeping pill prescriptions were written for drugs whose method of action depends upon boosting GABA levels in the brain. GABA (gamma-Aminobutyric acid) is a neurotransmitter which dampens the firing of neurons to calm brain activity. GABA works by suppressing Orexin, another neurotransmitter which increases alertness. Belsomra is a soporific which uses this same mechanism to suppress wakefulness in the brain and so aid sleep. It’s very popular due to its strong marketing drive, which promotes the drugs via TV adverts, a website and even its Sleep Guru app. A single month after it was approved by the FDA and released by Merck Pharmaceuticals, physicians were issuing as many as four thousand prescriptions for Belsomra per week. Belsomra has sold extremely well, so much so that Global Data, a UK consulting firm, has forecast Belsomra to be the best-selling soporific within an 8 year timeframe. Belsomra vs ambien How Is Belsomra Different From Ambien? PharmacistAnswers, What You Should Know Before Trying New Sleeping Pill Belsomra. Antabuse dosesOrder viagra mexicoHow to buy nolvadex Human Resources for the University of Oklahoma. Serving Faculty and Staff in Norman, Oklahoma City, and Tulsa campuses. Employees OU Human Resources. Belsomra vs Ambien Main Differences and Similarities. Belsomra Prices, Coupons & Savings Tips - GoodRx. Ambien vs Belsomra vs Lunesta vs Sonata Since the beginning of the 90s, the majority of sleeping pill prescriptions were written for drugs whose method of action depends upon boosting GABA levels in the brain. GABA gamma-Aminobutyric acid is a neurotransmitter which dampens the firing of neurons to calm brain activity. Lunesta vs. Ambien Two Short-term Treatments for Insomnia. Medically reviewed by Healthline's Medical Network on March 31, 2017 — Written by Ann Pietrangelo and the Healthline Editorial Staff. Belsomra suvorexant helps you fall asleep, but is only avaliable as a brand name so can be expensive. Ambien zolpidem aids in falling asleep and staying asleep, but it can be habit-forming and might be more likely than other sleep medicines to cause side effects.