Yes, because we do know that the combination has an increased risk of serotonin syndrome. No, because with the doses you mentioned the serotonin syndrome is rare and the combination you mentioned has been tried effectively with clinical benefits. Coadministration with sertraline may increase the plasma concentrations of some tricyclic antidepressants (TCAs). The proposed mechanism is sertraline inhibition of CYP450 2D6. Caution is advised if sertraline (or other SSRIs) is prescribed with TCAs. Pharmacologic response and plasma TCA levels should be monitored more closely whenever sertraline is added to or withdrawn from therapy in patients stabilized on their existing antidepressant regimen, and the TCA dosage adjusted as necessary You should be able to closely monitor for signs and symptoms of TCA toxicity (e.g., sedation, dry mouth, blurred vision, constipation, urinary retention) and/or excessive serotonergic activity (e.g., CNS irritability, altered consciousness, confusion, myoclonus, ataxia, abdominal cramping, hyperpyrexia, shivering, pupillary dilation, diaphoresis, hypertension, and tachycardia). These symptoms were well documented in the literature. WARNING: SUICIDALITY AND ANTIDEPRESSANT DRUGS ZOLOFT and other antidepressant medicines may increase suicidal thoughts or actions in some people 24 years of age and younger, especially within the first few months of treatment or when the dose is changed. Watch for these changes and call your healthcare provider right away if you notice new or sudden changes in mood, behavior, actions, thoughts, or feelings, especially if severe. Pay particular attention to such changes when ZOLOFT is started or when the dose is changed. Depression or other serious mental illnesses are the most important causes of suicidal thoughts or actions. Watch for these changes and call your healthcare provider right away if you notice new or sudden changes in mood, behavior, actions, thoughts, or feelings, especially if severe. Keep all follow-up visits with your healthcare provider and call between visits if you are worried about symptoms. Before taking ZOLOFT, tell your doctor and pharmacist about all prescription and over-the-counter medications and supplements you take or plan to take including: those to treat migraines, psychiatric disorders (including other antidepressants or amphetamines) to avoid a potentially life-threatening condition called serotonin syndrome; aspirin, other NSAID pain relievers, or other blood thinners because they may increase the risk of bleeding. Diflucan for men Www.zocor medication.com I have been on Zoloft Sertraline for 15 years vacillating between 100 to 150 mg per day. Over the last year I have felt like something wasn’t right and it was time to get away from this drug. I went from 100 mg to 50 mg and discussed this with my therapist. Doctors give trusted answers on uses, effects, side-effects, and cautions Dr. Ghanem on zoloft 150 mg side effects Lexapro escitalopram is an ssri and is basically the "pure" form of citalopram. Learn more about ZOLOFT® sertraline HCl, a prescription treatment for depression. if your co-pay or out-of-pocket cost is more than $150, you will save $150. I had been on 30mg of lexapro for six weeks and seemed to be getting worse. He had me switch to 100mg of zoloft for a week and then in a week increase to 150mg. Since I'v been at 150mg, I have felt very tired and more anxious at the same time. It has been causing me to take xanax again after almost stopping. Now I'm back to 1.0 to 1.5mg per day for the anxiety. Obviously, I don't like taking xanax because of the addiction potential. 150 mg by itself is not too much, depending on your size and weight, but it sounds like you have a paradoxical effect..anxiety rather than less, and this sometimes happens for people because Zoloft has a stimulating effect. Talk to your doctor about changing the medication.... I have post a week ago cause I was having bad headache from upping my zoloft dosage at 150. My headache are practicly gone and I felt better in the beginning of the week. I take the meds since two years and take it in the morning. You very well may need another couple of weeks before you start seeing improvements. But since two days, I feel sooooo tired, like I have no energy, my anxiety came back also. I just want to have my energy and feel less anxious...stop thinking or wondering constantly about my health!!! Its been 18 days now that my dose of zoloft is at 150mg and I still have anxiety. When I went back on Zoloft, I gradually increased my dose every couple of weeks, when I got to my current dose (150mg) I can say that it took me at least 3-4 weeks before I noticed a significant change, and the improvements kept coming, even a couple of months in, very gradually. Ive been at 100 for two years now and at 125 still last summer. It scares me that the med may not be effective anymore... Im still having tensions behind my head, feeling short of dizzy,... My experience was the longer I was on it, the better I felt, until I reached what I would call my "normal", which is literally little to no anxiety, and just overall, feeling so much better..energy, more motivation, getting more enjoyment out of life. Just like when you first start the Zoloft and have to wait a while until your body adjusts and you see some improvements, the same goes for the dosage increases. My advice to you is to hang in there, you've gotten this far..might be right on the cusp of big improvements. You might as well give it another few weeks before even considering making any determinations about the effectiveness of the Zoloft for you. Zoloft 150 Can 150mg of Zoloft be too much? - MedHelp, Zoloft 150 mg side effects - Answers on HealthTap Order synthroidDoxycycline hydrochlorideXanax vision problems Hi! I have post a week ago cause I was having bad headache from upping my zoloft dosage at 150. Its been two weeks today that I am at that dose. 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