Zoloft (Sertraline) is a selective serotonin reuptake inhibitor (SSRI) used to treat major depressive disorders, panic disorder, obsessive compulsive disorder (OCD), or post-traumatic stress disorder. Sertraline is also approved for the treatment of premenstrual dysphoric disorder (PMDD). It helps by decreasing anxiety and fear and can help to increase your interest in daily living. Your doctor may use this medicine to treat other conditions as well. Not every known side effect, adverse effect, or drug interaction is in this database. If you have questions about your medicines, talk to your health care provider. This drug relieves depression by slowly restoring a chemical in the brain (serotonin) to normal levels. Proper levels of serotonin are necessary for our well-being. Zoloft is the brand name of the generic medication sertraline hydrochloride. Zoloft is a prescription medication used to treat depression, anxiety disorders, and other serious mental health problems. Manufactured by Pfizer, Zoloft has been approved by the Food and Drug Administration (FDA) for the treatment of social anxiety disorder (SAD) since 2003 and is the only medication approved for long-term treatment. You must combine the liquid form of Zoloft with one of the following before use: water, ginger ale, lemon-lime soda, lemonade or orange juice. Combine the prescribed amount of medication with one half cup of the chosen liquid, and be sure to prepare each dose immediately before you take it, not in advance. In general, Zoloft is taken once daily, with or without food. If you forget to take a daily dose, take it when you remember. Zoloft grapefruit juice Propranolol night sweats For the treatment of OCD, Zoloft is not recommended for use in children under the age of 6, as the. Wait until the next day and take your normal dose then. Zoloft Sertraline is a selective serotonin reuptake inhibitor SSRI used to. depression by slowly restoring a chemical in the brain serotonin to normal levels. Jan 2, 2019. Zoloft sertraline is used to treat depression, obsessive-compulsive disorder. in larger or smaller amounts or for longer than recommended. I've been on zoloft 25 mg for two years and every time I see my doc he tries to up it telling me its not even a therapeutic dose. When I started the med I was feeling much worse anxiety/OCD then I am now so I feel it has helped. The thing you need to watch with Zoloft is whatever dose your on leave it alone my doctor had little to no exp. I'm sure I could feel better but I am anxious to up it, it was hard enough to take it at all since taking medications is a BIG hurdle for me. with these types of medication I started at 5 mg everytime I went back he would say did you notice a difference? I would say no and he would double it next thing I know it went from doing nothing to making me a zombie couldn't every find a correct dose took myself off of it and felt a lot better. One thing you have to watch and I've never seen anyone mention this or if was just me but marijuana and Zoloft adversely effect each other and things can get really bad hope this helps The 25 mg of Zoloft is considered a child's dose. Nevertheless, while I was suffering suicidal anxiety, 25 mg helped me ENORMOUSLY. When my psychiatrist was emphatic that 50 mg was the therapeutic dose for adults, I complied. When my doctor urged me to increase the dosage to 50 mg, I felt detached and "zoned out" every chance I got. Initial: 50 mg q Day PO given continuously throughout menstrual cycle or given during luteal phase only May increase by 50 mg at the onset of each new menstrual cycle; no more than 150 mg q Day when administered continuously or 100 mg q Day when administered during luteal phase only 25 mg PO q Day initially; may increase by 25 mg every 2-3 days; not to exceed 200 mg q Day Alzheimer dementia related depression: Start at 12.5 mg/day and titrate every 1-2 weeks to response; not to exceed 150-200 mg Renal impairment: Dose adjustment not necessary Mild hepatic impairment (Child-Pugh 5-6): Decrease recommended starting dose and therapeutic dose by 50% Moderate-to-severe hepatic impairment (Child-Pugh 7-15): Not recommended; sertraline is extensively metabolized, and the effects in patients with moderate and severe hepatic impairment have not been studied Clinical worsening and suicide ideation may occur despite medication Use caution in patients with seizure disorders May worsen mania symptoms or precipitate mania in patients with bipolar disorder Increases risk of hyponatremia and impairment of cognitive/motor functions in the elderly Increases risk of bleeding in patients taking anticoagulants/antiplatelets concomitantly Risk of mydriasis; may trigger angle closure attack in patients with angle closure glaucoma with anatomically narrow angles without a patent iridectomy Pregnancy: Conflicting evidence regarding use of SSRIs during pregnancy and increased risk of persistent pulmonary hypertension of the newborn (see Pregnancy) In neonates exposed to SNRIs/SSRIs late in third trimester: Risk of complications such as feeding difficulties, irritability, and respiratory problems Avoid abrupt withdrawal Bone fractures reported with antidepressant therapy; consider the possibility if patient presents with bone pain, bruising, or point of tenderness Coadministration with other drugs that enhance the effects of serotonergic neurotransmission (eg, tryptophan, fenfluramine, fentanyl, 5-HT agonists, St. John’s Wort) should be undertaken with caution and avoided whenever possible due to the potential for pharmacodynamic interaction (see Contraindications) May cause false-positive urine immunoassay screening tests for benzodiazepines SSRIs and SNRIs are associated with development of SIADH; hyponatremia reported Several SSRIs (eg, fluoxetine, fluvoxamine, paroxetine, sertraline) are metabolized by CYP2D6 CYP2D6 is involved in the metabolism of approximately 20% of drugs in clinical use and displays large individual-to-individual variability in activity due to genetic polymorphisms More than 80 CYP2D6 variant alleles have been identified; however, 4 of the most prevalent alleles, CYP2D6*3, *4, *5, and *6, account for 93-97% of CYP2D6 poor metabolizers CYP2D6*4, the most common variant (~25% frequency in whites), causes a splicing defect; CYP2D6*3 (2.7% frequency) causes a frameshift mutation; and CYP3D6*5 (2.6%) is an entire deletion of the CYP2D6 gene; individuals homozygous for these alleles have no CYP2D6 activity The impact of CYP2D6 activity is further complicated in some SSRIs (eg, fluoxetine, fluvoxamine, paroxetine, sertraline) because in addition to being substrates for CYP2D6, they are also known to moderately inhibit CYP2D6 activity The above information is provided for general informational and educational purposes only. Individual plans may vary and formulary information changes. Contact the applicable plan provider for the most current information. Zoloft normal dosage Sertraline 50 mg daily the optimal dose in the treatment of depression., Zoloft Side Effects, Uses & Dosage - Psych Central Amoxil 500 Sertraline Zoloft is an oral medication used to treat major depressive disorder and. An increase in activity or talking more than normal; Serotonin syndrome. Sertraline Side Effects, Dosage, Uses & More - Healthline. Zoloft Uses, Dosage, Side Effects & Warnings -. Zoloft sertraline dosing, indications, interactions, adverse effects, and.. Sertraline/Sertraline Hydrochloride/Zoloft Oral Tab 25mg, 50mg, 100mg. Dosage adjustments of sertraline are recommended in patients with hepatic disease. In the in United States it is sold under the brand name Zoloft. The recommended dosage of sertraline depends on the disorder being treated. The initial. Nov 12, 2018. In general, Zoloft is taken once daily, with or without food. If you forget to take a daily dose, take it when you remember. However, if it is close to.