In the Scandinavian Simvastatin Survival Study (a placebo-controlled, randomized clinical trial of five years' duration), simvastatin reduced overall mortality in people with existing cardiovascular disease and high LDL cholesterol by 30% and reduced cardiovascular mortality by 42%. The risks of heart attack, stroke, or needing a coronary revascularization procedure were reduced by 37%, 28%, and 37%, respectively. The Heart Protection Study evaluated the effects of simvastatin in people with risk factors including existing cardiovascular disease, diabetes, or stroke, but having relatively low LDL cholesterol. In this trial, which lasted 5.4 years, overall mortality was reduced by 13% and cardiovascular mortality was reduced by 18%. People receiving simvastatin experienced 38% fewer nonfatal heart attacks and 25% fewer strokes. Results from one trial showed participants assigned to simvastatin had lower odds (0.51 OR) of having AMD progression at three years compared to those assigned to placebo, though the results were not significant. A type of DNA variant known as a single nucleotide polymorphism (SNP) may help predict individuals prone to developing myopathy when taking simvastatin; a study ultimately including 32,000 patients concluded the carriers of one or two risk alleles of a particular SNP, rs4149056, On March 19, 2010, the FDA issued another statement regarding simvastatin, saying it increases the risk of muscle injury (myopathy) when taken at high doses or at lower doses in combination with other drugs. Simvastatin is used together with diet, weight-loss, and exercise to reduce the risk of heart attack and stroke and to decrease the chance that heart surgery will be needed in people who have heart disease or who are at risk of developing heart disease. Simvastatin is also used to decrease the amount of fatty substances such as low-density lipoprotein (LDL) cholesterol (''bad cholesterol'') and triglycerides in the blood and to increase the amount of high-density lipoprotein (HDL) cholesterol (''good cholesterol'') in the blood. Simvastatin may also be used to decrease the amount of cholesterol and other fatty substances in the blood in children and teenagers 10 to 17 years of age who have familial heterozygous hypercholesterolemia (an inherited condition in which cholesterol cannot be removed from the body normally). Simvastatin is in a class of medications called HMG-Co A reductase inhibitors (statins). It works by slowing the production of cholesterol in the body to decrease the amount of cholesterol that may build up on the walls of the arteries and block blood flow to the heart, brain, and other parts of the body. Take simvastatin at around the same time every day. Accumulation of cholesterol and fats along the walls of your arteries (a process known as atherosclerosis) decreases blood flow and, therefore, the oxygen supply to your heart, brain, and other parts of your body. Follow the directions on your prescription label carefully, and ask your doctor or pharmacist to explain any part you do not understand. Do not take more or less of it or take it more often than prescribed by your doctor. Lowering your blood level of cholesterol and fats with simvastatin has been shown to prevent heart disease, angina (chest pain), strokes, and heart attacks. This medication may be prescribed for other uses; ask your doctor or pharmacist for more information. Your doctor may start you on a low dose of simvastatin and gradually increase your dose, not more than once every 4 weeks. Diflucan for children Order accutane online uk Niaspan ER plaque buildup, niaspan, hdl cholesterol, good cholesterol, trigs Hang in there everyone-Niaspan ER-is one of the best medications you could ever be on. I have been on it over 2 years. I have been on it over 2 years. Diabetes Simvastatin, like other medications in this family, may cause a loss of. Coadministration of certain drugs may need to be avoided or dosage adjustments may be necessary; review drug interactions. Simvastatin is FDA-approved for. The treatment of high cholesterol has improved care for many people. Most people who have diabetes or those who have had a stroke or heart attack benefit from lower cholesterol levels. Medications called “statins” are the most commonly prescribed drugs used to reduce cholesterol. Some examples of statin medications are Lipitor® (atorvastatin), Pravachol® (pravastatin), Zocor® (simvastatin), Livalo® (pitavastatin) and Crestor® (rosuvastatin). Unfortunately, some people may experience muscle pain or weakness while taking statins. The pain may be minor such as soreness or stiffness. However, muscle pain, particularly if severe and accompanied by dark-colored urine, may be an indication of a more serious, life-threatening problem called rhabdomyolysis. The information you provide may be used to send you health-related materials and to develop products, services, and programs. We may also contact you to participate in market research. Astra Zeneca, or third parties working on our behalf, will not sell or rent personal health information. In the future, if you no longer want to receive health-related materials or wish to be contacted, call The information you provide may be used to send you health-related materials and to develop products, services, and programs. We may also contact you to participate in market research. Astra Zeneca, or third parties working on our behalf, will not sell or rent personal health information. Www.zocor medication.com Managing Muscle Pain Related to Cholesterol Medication, Zocor - Uses, Side Effects, Interactions - Viagra 25mg price in indiaAmoxicillin 875 mg side effectsDoxycycline bladder infection Simvastatin oral tablet is available as the brand-name drug Zocor. It's also available as a generic drug. Generic drugs usually cost less than the brand-name. Simvastatin Side Effects, Dosage, Usage, and More - Healthline. Zocor simvastatin dose, indications, adverse effects, interactions.. Zocor simvastatin Side Effects, Interactions, Uses & Drug Imprint. How to use Zocor. Take this medication by mouth as directed by your doctor, usually once daily in the evening. If you are using the tablet form of this medication, you may take this medication. COREG, COREG CR, and TILTAB are trademarks owned by or licensed to the GSK group of companies. The other brand listed is a trademark owned by or licensed to its owner and is not owned by or licensed to the GSK group of companies. Decreased elimination of simvastatin could. Examples of drugs that decrease.