Fluconazole contraindications

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    Fluconazole contraindications


    albicans) species, Aspergillus flavus, Aspergillus fumigatus, Coccidioides immitis, and Histoplasma capsulatum. The spectrum of activity includes Cryptococcus neoformans, Candida (including systemic C. Antifungal action: Fluconazole exerts its fungistatic effects by inhibiting fungal cytochrome P-450. For suppression of relapse in patients with AIDS, give 200 mg once daily. Continue treatment for 10 to 12 weeks after CSF culture becomes negative. Distribution: Well distributed to various sites, including CNS, saliva, sputum, blister fluid, urine, normal skin, nails, and blister skin. CNS levels of drug approach 50% to 90% of that of serum. Selected from data included with permission and copyrighted by First Databank, Inc. This copyrighted material has been downloaded from a licensed data provider and is not for distribution, expect as may be authorized by the applicable terms of use. CONDITIONS OF USE: The information in this database is intended to supplement, not substitute for, the expertise and judgment of healthcare professionals. The information is not intended to cover all possible uses, directions, precautions, drug interactions or adverse effects, nor should it be construed to indicate that use of a particular drug is safe, appropriate or effective for you or anyone else. A healthcare professional should be consulted before taking any drug, changing any diet or commencing or discontinuing any course of treatment.

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    Fluconazole contraindications and cautions. fluconazole. generic. Sections email. No Formulary Selected. Contraindications / Cautions FAQ about this section. Hepatic failure Unnecessary, however, thoughtful use of fluconazole with close. Contraindications Concurrent administration with astemizole or cisapride. Fluconazole significantly increased the QTc interval in subjects receiving cisapride 20 mg four times daily for 5 days. See CONTRAINDICATIONS and.

    Fluconazole is a first-generation triazole antifungal medication. It differs from earlier azole antifungals (such as ketoconazole) in that its structure contains a triazole ring instead of an imidazole ring. While the imidazole antifungals are mainly used topically, fluconazole and certain other triazole antifungals are preferred when systemic treatment is required because of their improved safety and predictable absorption when administered orally. Fluconazole's spectrum of activity includes most Candida species (but not Candida krusei or Candida glabrata), Cryptococcus neoformans, some dimorphic fungi, and dermatophytes, among others. Common uses include: Fungal resistance to drugs in the azole class tends to occur gradually over the course of prolonged drug therapy, resulting in clinical failure in immunocompromised patients (e.g., patients with advanced HIV receiving treatment for thrush or esophageal Candida infection). albicans, resistance occurs by way of mutations in the ERG11 gene, which codes for 14α-demethylase. These mutations prevent the azole drug from binding, while still allowing binding of the enzyme's natural substrate, lanosterol. glabrata is increasing the rate of efflux of the azole drug from the cell, by both ATP-binding cassette and major facilitator superfamily transporters. Development of resistance to one azole in this way will confer resistance to all drugs in the class. Other gene mutations are also known to contribute to development of resistance. Read the Patient Information Leaflet if available from your pharmacist before you start taking fluconazole and each time you get a refill. If you have any questions, ask your doctor or pharmacist. Take this medication by mouth with or without food as directed by your doctor, usually once daily. If you are taking the liquid suspension form of this medication, shake the bottle well before each dose. Carefully measure the dose using a special measuring device/spoon. Do not use a household spoon because you may not get the correct dose. Dosage is based on your medical condition and response to treatment. Generally in children, the dose should not exceed 600 milligrams daily unless directed by the doctor.

    Fluconazole contraindications

    Contraindications for Fluconazole Oral - WebMD, Fluconazole -

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  4. Coadministration of terfenadine is contraindicated in patients receiving fluconazole at multiple doses of 400mg per day or higher based upon results of a.

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    Diflucan/Fluconazole Oral Pwd F/Recon 1mL, 10mg, 40mg. Diflucan/Fluconazole. Some drug-drug combinations may be contraindicated. OBRA guidelines. Fluconazole DiFlucan. Pharmacologic classification bis-triazole derivative. Contraindicated in patients hypersensitive to drug and other drugs in same class. Fluconazole is used to treat vaginal yeast infections. It works by stopping the growth of common types of vaginal yeast fungus. Learn about side effects, drug.

     
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