This content has not been reviewed within the past year and may not represent Web MD's most up-to-date information. To find the most current information, please enter your topic of interest into our search box. " July 19, 2002 -- Chemotherapy may not be necessary for preventing some types of breast cancer from coming back in postmenopausal women. A new report shows treatment with the drug tamoxifen may be enough to prevent recurrence in these women, without the negative side effects that come with chemotherapy. women with breast cancers that have spread to the lymph nodes, the standard therapy includes a short course of chemotherapy followed by treatment with tamoxifen. But other experts say it's still too soon to consider withholding chemotherapy from women who have already suffered from breast cancer once, despite the potential side effects of chemotherapy. Although previous studies have shown that tamoxifen is effective at preventing tumors from coming back in women who have a type of breast cancer that grows when exposed to estrogen (known as estrogen-receptor or ER positive), researchers say there has been little evidence that chemotherapy provides any additional benefit for these women. The study, published in the July 17 issue of the Journal of the National Cancer Institute, involved 1,669 postmenopausal women who had undergone surgery to remove breast cancers that had not spread to the surrounding lymph nodes. To determine the impact of adding chemotherapy to tamoxifen use, the researchers randomly divided the women into two groups. Researchers say about half the women who had surgery for breast cancer between 19 in the U. One group received chemotherapy followed by tamoxifen and the other received tamoxifen alone for five years. side effect of tamoxifen is blood clots, including deep vein thrombosis (DVT) and pulmonary embolus. In some cases, health care professionals may use the trade name Nolvadex when referring to the generic drug name tamoxifen. This medication is classified as an "anti-estrogen." (For more detail, see "How this drug works" section below). You should seek emergency help and notify your health care provider immediately if you develop sudden chest pain and shortness of breath. Notify your health care provider within 24 hours if you notice that one leg is swollen, red, painful and/or warm to touch and the other is not. A side effect of tamoxifen can be the development of uterine cancer. Women who have not had a hysterectomy should have regular pap smears and gyn examinations. Abnormal vaginal bleeding should be reported to your health care provider. Doxycycline emedicine Metformin food Oct 16, 2018. Tamoxifen is the oldest of the hormonal therapies, drugs that block the effects of estrogen in the breast tissue. Tamoxifen is approved by the. Oct 28, 2014. Tamoxifen is the generic form of the brand-name drug Soltamox, which is. To make sure you can safely take tamoxifen, tell your doctor if you. Dec 19, 2014. Tamoxifen is a SERM selective estrogen receptor modulator. SERMs block the action of estrogen in breast and certain other cells by sitting in. Tamoxifen is a hormone therapy drug taken by many premenopausal women after completing their initial treatments for estrogen receptor positive breast cancer. To treat the side effects of tamoxifen (such as hot flashes) and to help with depression, doctors often prescribe antidepressants. Yet many antidepressants can interfere, or completely cancel out, the benefits of tamoxifen. Once a woman is finished with the primary treatment of breast cancer, with therapies such as surgery, chemotherapy, and radiation therapy, she may need to take tamoxifen. For women who have estrogen receptor positive tumors, hormone therapy can reduce the risk of the cancer coming back (recurrence) by around 50 percent. The choice of medication depends on menopausal status. If a woman is premenopausal, tamoxifen is usually the drug of choice. (For those who are postmenopausal, or who are premenopausal but have received ovarian suppression therapy, an aromatase inhibitor is usually used instead). Tamoxifen (Nolvadex®) is a medication in pill form that has been used for more than 25 years to treat breast cancer in women and men. Tamoxifen is one of the most common endocrine therapy drugs. It has been shown to decrease the chance of recurrence in some early-stage breast cancers and to prevent the development of cancer in the opposite breast. Tamoxifen can also slow or stop the growth of cancer cells present in the body. There are an estimated 29 million women at increased risk for breast cancer in this country, and tamoxifen may offer another alternative to watchful waiting or prophylactic (preventative) mastectomy. Tamoxifen is classified as a selective estrogen receptor modulator (SERM) and works as an anti-estrogen: While the hormone estrogen promotes the growth of breast cancer cells, tamoxifen works by blocking estrogen from attaching to estrogen receptors on these cells. By blocking the estrogen receptors, it is believed that the growth of the breast cancer cells will be halted. Is tamoxifen safe Drugs to Avoid for Women Taking Tamoxifen - Stop Cancer Fund, Tamoxifen Nolvadex - Side Effects, Dosage, Interactions - Drugs Sertraline brain fogDuloxetine for osteoarthritisBuy accutane online with paypalAzithromycin courseWhat prednisone Tamoxifen with the possible side effects, which can be quite. Tamoxifen as part of their treatment plan following a. Is Tamoxifen safe? What are the major. To Tamoxifen or not? - Breast Cancer Network Australia. Tamoxifen's Benefits Long-Lasting for High-Risk Women. Tamoxifen in Pregnancy Safety Concerns - Verywell Health. Dec 16, 2018. To treat the side effects of tamoxifen such as hot flashes and to help with. Antidepressant Drug, Interaction with Tamoxifen, Safety Range. Oct 26, 2017. Harry Connick Jr.'s wife Jill Goodacre has been taking tamoxifen since her breast cancer surgery. Here are the facts on tamoxifen's side effects. Find information about tamoxifen, a medicine to treat breast cancer, from Cleveland Clinic, including side effects, precautions, concerns, and more.