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    Isotretinoin, also known as 13-cis-retinoic acid (and colloquially referred to by its former brand name Accutane or Roaccutane), is a medication primarily used to treat severe acne. Rarely, it is also used to prevent certain skin cancers (squamous-cell carcinoma), and in the treatment of other cancers. It is used to treat harlequin-type ichthyosis, a usually lethal skin disease, and lamellar ichthyosis. It is a retinoid, meaning it is related to vitamin A, and is found in small quantities naturally in the body. Isotretinoin is primarily used as a treatment for severe acne. The most common adverse effects are a transient worsening of acne (lasting 1–4 months), dry lips (cheilitis), dry and fragile skin, and an increased susceptibility to sunburn. Uncommon and rare side effects include muscle aches and pains (myalgias), and headaches. Isotretinoin is known to cause birth defects due to in-utero exposure because of the molecule's close resemblance to retinoic acid, a natural vitamin A derivative which controls normal embryonic development. ” Go ahead and ask ten people…you’ll get ten different answers. You have planned, prepared, and packed for the big trip. I’m not talking about basic items that are already part of your packing routine, such as a small power strip and outlet adapters... Then…first day out, you start to feel a “rub” in your shoe. At first, you do nothing, maybe adjust your socks or retie your... The Galicia region of Spain is cool and wet; it’s often compared to Ireland. This gazpacho recipe is the guarantee for “instant summer” any time of year. Beautiful and green, with lots of mist and rain, so there’s a lingering dampness... Originally introduced to Spain by Roman soldiers, it was a simple soup meant to soften stale bread with some type of liquid. Updated June 27, 2018 The Camino de Santiago: How I Started…like many grand schemes, it began with a vague notion that simmered for a decade. Then–who knows how or why–suddenly a 500-mile walk seemed like a perfectly reasonable thing... Tortilla: In Spain, it means the classic egg-and-potato pie that shows up in every bar.

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    Accutane — the drug that cleared severe acne but was also linked to depression, suicidal thoughts and fetal deformities — is still on the market in its generic form, isotretinoin. How can this be, given that the original drug was discontinued by its manufacturer Hoffmann-La Roche, in part due to lawsuits relating to inflammatory bowel diseases and other issues? With intense patient screening, compliance protocols and careful monitoring, isotretinoin (eye-soh-tret-in-OH-in) can be effective and the risk of terrible side effects can be minimized. Isotretinoin is not without problems, however, so patients need to weigh the risks and the benefits before taking the drug. Here are 9 things you should know about isotretinoin. They can help you gauge whether it is a drug you want to take yourself or have prescribed for your teen to treat severe acne. In 1982, the US Food and Drug Administration () approved the active ingredient isotretinoin for use in treating severe nodular acne, under the brand name Accutane. Women must avoid becoming pregnant while taking this medication. Serious (sometimes fatal) birth defects, miscarriages, and premature births have occurred when this drug has been used during pregnancy. For female patients, two effective forms of birth control (or complete avoidance of sexual intercourse) must be used for 1 month before starting isotretinoin, during use, and for 1 month after stopping this drug. You must also have monthly pregnancy-avoidance counseling from your doctor. Do not use "minipills" for birth control (non-estrogen-containing pills) since they may not work as well with isotretinoin. If you are late in having your period, or if you have sexual intercourse at any time without using two effective forms of birth control, stop taking this medication and contact your doctor right away. (See also the Precautions section.)After December 31, 2005, only patients enrolled in the i PLEDGE program may obtain and use isotretinoin.

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