Viagra research

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  1. vasyan Well-Known Member

    Viagra research


    In clinical studies, VIAGRA was assessed for its effect on the ability of men with erectile dysfunction (ED) to engage in sexual activity and in many cases specifically on the ability to achieve and maintain an erection sufficient for satisfactory sexual activity. VIAGRA was evaluated primarily at doses of 25 mg, 50 mg and 100 mg in 21 randomized, double-blind, placebo-controlled trials of up to 6 months in duration, using a variety of study designs (fixed dose, titration, parallel, crossover). VIAGRA was administered to more than 3,000 patients aged 19 to 87 years, with ED of various etiologies (organic, psychogenic, mixed) with a mean duration of 5 years. VIAGRA demonstrated statistically significant improvement compared to placebo in all 21 studies. The studies that established benefit demonstrated improvements in success rates for sexual intercourse compared with placebo. The effectiveness of VIAGRA was evaluated in most studies using several assessment instruments. The primary measure in the principal studies was a sexual function questionnaire (the International Index of Erectile Function - IIEF) administered during a 4-week treatment-free run-in period, at baseline, at follow-up visits, and at the end of double-blind, placebo-controlled, at-home treatment. The little blue pill may not have ever been if not for one dutiful nurse. Viagra, Pfizer’s blockbuster erectile dysfunction drug hit the market in 1998. In 20 years, it’s become ubiquitous: 62 million men all over the world have bought the drug, according to a Pfizer spokesperson. The US military shells out $41.6 million per year for it, and from 2012 onward, the US, Mexico, and Canada spent about $1.4 billion on it annually (although those numbers are projected to fall in the coming years when Pfizer’s patent on the drug expires in 2020). Despite the drug’s popularity today, the researchers who discovered it weren’t even looking for it. Sildenafil, the active ingredient in Viagra, was originally developed to treat cardiovascular problems. It was meant to dilate the heart’s blood vessels by blocking a particular protein called PDE-5.

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    Developing a new medicine is a long and expensive process. The Viagra™ story started as long ago as 1985. Roll over the segments on the chart to see more information about its life. Sep 10, 2017. Viagra's famously surprising origin story is actually a pretty common. Despite the drug's popularity today, the researchers who discovered it. Jul 25, 2018. Pregnant women took generic Viagra in a clinical drug trial. form of high blood pressure in the lungs, which killed them, the researchers said.

    Dr Wheate in the past has received funding from the ACT Cancer Council, Tenovus Scotland, Medical Research Scotland, Scottish Crucible and the Scottish Universities Life Sciences Alliance for research into platinum drugs. Dr Wheate is a named inventor on two international patents dealing with the drug delivery of anticancer drugs. Viagra is one brand name of a drug that is used to treat erectile dysfunction (impotence): the inability to get, and maintain, an erection. It is also used in the treatment of high blood pressure specific to the heart and the arteries that feed the lungs. The generic name of the drug is sildenafil (pronounced sill-den-a-fill). Like many great scientific discoveries, the benefits of Viagra in treating erectile dysfunction were discovered by accident. The pharmaceutical company Pfizer initially developed the drug in 1989 as a treatment for high blood pressure and angina. The "little blue pill" could one day have a surprising use: as a cancer prevention drug. Early research in mice suggests that small doses of sildenafil, the ingredient in Viagra responsible for the pill's effects, may prevent colorectal cancer. When the researchers gave the drug to mice that were prone to developing colorectal cancer, the drug was linked to a 50 percent reduction in the number of precancerous polyps that formed in the animals' intestines, compared with mice that weren't given the drug. Still, much more work is needed before researchers will know if Viagra has the same effect in people, the study researchers said. [Viagra Goes Generic: 5 Interesting Facts About the ' Little Blue Pill'] Next steps include testing Viagra in a clinical trial of patients who have a high risk of colorectal cancer, such as people with a family history of the disease, study co-author Darren Browning, a cancer researcher at Augusta University Georgia Cancer Center, said in a statementearlier this month. The mice used in the study had a mutation in a gene called "adenomatous polyposis coli" or APC. This mutation is also found in humans and results in the formation of hundreds of polyps starting in the teenage years, and these growths lead to colorectal cancer, Browning said.

    Viagra research

    Viagra has the potential to be used as a treatment for rare cancers., How Viagra was discovered by Pfizer — Quartz

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  4. Viagra has moved from the bedroom to the locker room. The buzz on the street was that Yankee superstar Roger Clemens had a bottle of Viagra disguised as vitamin pills stashed in his locker Viagra The Latest Research on Exercise Performance

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    There are approximately 1,000 Viagra Research in the U. S. who are certified to perform this procedure. LANAP is the only patented periodontal surgical procedure. It also has 510K clearance from the U. S. Food and Drug Administration. In clinical studies, VIAGRA was assessed for its effect on the ability of men with erectile. At the end of the long-term study, 88% of patients reported that VIAGRA. Each symbol represents the percentage of men with at least 60% success with viagra or placebo. Size of the symbol is proportional to the size of the study.

     
  5. milady User

    Zoloft (Sertraline) is a selective serotonin reuptake inhibitor (SSRI) used to treat major depressive disorders, panic disorder, obsessive compulsive disorder (OCD), or post-traumatic stress disorder. Sertraline is also approved for the treatment of premenstrual dysphoric disorder (PMDD). It helps by decreasing anxiety and fear and can help to increase your interest in daily living. Your doctor may use this medicine to treat other conditions as well. Not every known side effect, adverse effect, or drug interaction is in this database. If you have questions about your medicines, talk to your health care provider. This drug relieves depression by slowly restoring a chemical in the brain (serotonin) to normal levels. Proper levels of serotonin are necessary for our well-being. Zoloft Sertraline Hcl Side Effects, Interactions, Warning, Dosage. How Zoloft Is Used to Treat Social Anxiety Disorder - Verywell Mind Sertraline - dose, children, effects, therapy, drug, people, used, brain
     
  6. Petruchio XenForo Moderator

    Metformin acts primarily to suppress glucose production in the liver. While metformin's mechanism(s) of action remain controversial, current evidence indicates that metformin's most important effect in treating diabetes is to lower the hepatic production of glucose (as summarized in the top left box). Current evidence suggests that results from a combination of intracellular effects in the liver. When metformin is taken orally, it is absorbed into hepatocytes from the portal vein through plasma membrane transporters, including the organic cation transporter 1 (OCT1). Inside the cell metformin inhibits mitochondrial respiratory-chain complex 1, resulting in reduced ATP levels and increased AMP. Increased AMP levels activate Adenosine Monophosphate-Activated Protein Kinase (AMPK), which contributes to lowering of glucose production by at least 2 pathways: i) increased AMPK phosphorylates CBP & CRTC2 transcription factors, which inhibits genes involved in the production of glucose (“gluconeogenic genes”); ii) increased AMPK also inhibits mitochondrial glycerol-3-phosphate dehydrogenase (m GPD), leading to an increase in cytosolic NADH, which both stimulates the conversion of pyruvate to lactate, and simultaneously decreases gluconeogenesis. An accumulation of lactate to dangerous levels () can occur when metformin is taken by patients with other conditions resulting metabolic acidosis (liver disease, heart failure, sepsis, alcohol abuse), or kidney disease (as indicated by elevated creatinine levels) because metformin is eliminated by renal excretion) (He & Wondisford, 2015; Nolte Kennedy & Masharani, 2015). Glycemic mechanism of action of thiazolidinedione “insulin sensitizers” (using an adipocyte for illustration purposes). PPARγ stimulation upregulates the expression of genes involved in lipid & glucose metabolism, insulin signal transduction, and adipocyte differentiation. Oral hypoglycemic agents Hypoglycemic Drugs - TMedWeb Metformin Oral Route Precautions - Mayo Clinic
     
  7. GoldenEye XenForo Moderator

    What Are The Natural Alternatives To Cialis Tadalafil? What Are The Natural Alternatives To Cialis. The only disadvantage of this natural alternative to Cialis is that it takes two-three months of daily use to cure.

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