Sertraline hot flashes

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    Sertraline hot flashes


    • Venlafaxine inhibits the reuptake of serotonin and norepinephrine in the brain. • The reuptake effects of venlafaxine are dose dependent. At low doses it blocks only serotonin neurotransmission. At higher doses venlafaxine blocks neurotransmission of both serotonin and noradrenaline. • Sertraline undergoes extensive hepatic metabolism by CYP enzymes. The drug is primarily metabolized by CYP3A4 to its active metabolite N-desmethylsertraline and several other metabolites. Nevertheless both sertraline and venlafaxine may lead to significant weight gain. • Discontinuation syndrome Sertraline may be associated with a lower symptom burden during treatment discontinuation Hot flashes and night sweats are common vasomotor symptoms during the peri- and early post-menopausal period. One pharmaceutical company can now brag about a nonhormonal option to treat hot flashes during menopause. Noven Therapeutics knows that's welcome news to scores of women who've developed a fear of hormone therapy following the increased risk of heart disease and breast cancer seen in the Women's Health Initiative (WHI). But Brisdelle is just an old medication dressed up in a new feminine name and packaging – it's the antidepressant paroxetine, better known by its brand name, Paxil. "Some women won't even know it is an antidepressant," says Diana Zuckerman, Ph D, president of the National Center for Women & Families, a women's health advocacy group, explaining that few may look at the generic name, and of those who do, paroxetine will be much less recognizable than Paxil. Gynecologists have long been using them off-label to treat hot flashes, particularly in women who can't tolerate hormone therapy – including those with a history of heart disease, blood clots, deep vein thrombosis, and stroke. In theory, selective serotonin reuptake inhibitors (SSRIs) like paroxetine work for hot flashes because serotonin is thought to play a role in regulating body temperature. But the question remains as to whether antidepressants are actually effective in this condition. There are no large studies of their off-label use in hot flashes, and efficacy findings in the Brisdelle studies were questionable -- so much so that the FDA's own advisory committee recommended against approving the drug for hot flashes.

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    Moved Permanently. The document has moved here. Sep 4, 2015. But SSRIs, including Zoloft, are prescribed for a variety of disorders besides depression, including bulimia, hot flashes, obsessive-compulsive. Hot flashes and night sweats are common vasomotor symptoms during the peri- and early post-menopausal period. Women have variable responses when treated with antidepressants for their hot flashes. Venlafaxine is effective in reducing the frequency and severity of hot flashes 8.

    (CNN) -- Just after she'd gotten a divorce and gone back to work, Alice Thornton would feel cold one minute and hot the next, and her temper was shorter than usual. "It was irritating because when it comes, it comes roaring through," said Thornton, 61, of Huntington, West Virginia, whose symptoms began around age 49 or 50. A deficiency in the hormone estrogen is responsible for the symptoms of menopause, which include mood swings, hot flashes, sleep disruption and changes in libido. As baby boomers continue to go through menopause in record numbers, questions about how to curb these symptoms, especially those that interrupt daily life, are all the more relevant. At the same time, research on hormone replacement therapy keeps emerging without hard conclusions, leading doctors to recommend the lowest dose for the shortest duration. Not every woman feels troublesome effects from menopause; in fact, 30 percent don't report any significant symptoms. But that means up to 70 percent of women have moderate to severe symptoms that can cause changes in daily living, said women's health expert Dr. For 80 percent of women, symptoms generally resolve within five years, but it's not known how long the unpleasantness lasts beyond that for the remaining 20 percent of women, Moore said. Because every woman is different, there is no certain quick fix for menopausal symptoms. The study - conducted in nonhuman primates with brain structures and functions similar to those of humans - found that the antidepressant sertraline, a selective serotonin reuptake inhibitor (SSRI) marketed as Zoloft, significantly increased the volume of one brain region in depressed subjects but decreased the volume of two brain areas in non-depressed subjects. "These observations are important for human health because Zoloft is widely prescribed for a number of disorders other than depression," said Carol A. D., professor of pathology-comparative medicine at Wake Forest Baptist and lead author of the study, published in the current online issue of the journal Neuropharmacology. In the study, 41 middle-aged female monkeys were fed a diet formulated to replicate that consumed by many Americans for 18 months, during which time depressive behavior in the animals was recorded. Female monkeys were chosen for this study because depression is nearly twice as common in women as men and the use of antidepressants is most common in women ages 40 to 59. After the 18-month pre-study phase, the monkeys were divided into two groups balanced for body weight, body mass index and depressive behavior. For the next 18 months, 21 monkeys received sertraline in daily doses comparable to those taken by humans while a group of 20 received a placebo. This treatment regimen is analogous to a human taking an antidepressant for approximately five years.

    Sertraline hot flashes

    Smas-qa221_6-antidepressants-hot-flushes-final, Common antidepressant sertraline may change brain structures

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  3. So, these researchers believe that an 11% reduction in the hot flash score represents an effective alternative treatment. Numerous studies have shown that treatment with placebo can reduce hot flashes by 20-40%. In the Zoloft and hot flashes study, 15 women dropped out, six because of adverse reactions to the drug, 9 without giving reason.

    • Facts About Zoloft And Hot Flashes - EzineArticles.
    • Venlafaxine Effexor vs Sertraline Zoloft -.
    • Sertraline for treating Hot Flashes Treato.

    Jun 25, 2014. A study has found that the antidepressant Effexor chemical name venlafaxine eased hot flashes just as well as hormone replacement therapy. Consumer Medicine Information CMI about Zoloft Sertraline hydrochloride intended for persons living in Australia. Here are the side effects I had - for the first two weeks, anxious every day, hot flashes, cold chills, fell asleep quickly, but always woke up at 4 a.m. and couldn't.

     
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