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    Sildenafil action


    Sildenafil (Viagra) is used to treat erectile dysfunction (impotence; inability to get or keep an erection) in men. Sildenafil (Revatio) is used to improve the ability to exercise in adults with pulmonary arterial hypertension (PAH; high blood pressure in the vessels carrying blood to the lungs, causing shortness of breath, dizziness, and tiredness). Children should not usually take sildenafil, but in some cases, a doctor may decide that sildenafil (Revatio) is the best medication to treat a child's condition. Sildenafil is in a class of medications called phosphodiesterase (PDE) inhibitors. Sildenafil treats erectile dysfunction by increasing blood flow to the penis during sexual stimulation. Sildenafil treats PAH by relaxing the blood vessels in the lungs to allow blood to flow easily. If you are taking sildenafil to treat erectile dysfunction, you should know that it does not cure erectile dysfunction or increase sexual desire. Sildenafil does not prevent pregnancy or the spread of sexually transmitted diseases such as human immunodeficiency virus (HIV). However, patient may take drug 30 minutes to 4 hours before sexual activity. as a single dose, p.r.n., 1 hour before sexual activity. Based on effectiveness and tolerance by patient, may increase dose to maximum single dose of 100 mg or decrease dose to 25 mg. A maximum recommended dosing frequency is once daily. Erectile action: Sildenafil has no direct relaxant effect on isolated human corpus cavernosum, but enhances the effect of nitric oxide (NO) by inhibiting phosphodiesterase type 5 (PDE5), which is responsible for degradation of cyclic guanosine monophosphate (c GMP) in the corpus cavernosum. When sexual stimulation causes local release of NO, inhibition of PDE5 by sildenafil causes increased levels of c GMP in the corpus cavernosum, resulting in smooth muscle relaxation and inflow of blood to the corpus cavernosum. Absorption: Rapidly absorbed after oral administration. A high-fat meal delays the rate of absorption by about 1 hour and reduces peak levels by one-third.

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    See risks and benefits of VIAGRA® sildenafil citrate. Find causes of erectile dysfunction ED, or impotence. Learn how VIAGRA® can help treat ED. Sildenafil Viagra to the rescue! Sildenafil is a phosphodiesterase-5 inhibitor. It rescues the party by stopping PDE-5 from reducing the amount of cGMP in the penis. Sildenafil is a common medication used to stimulate erections in men with erectile dysfunction ED and treat certain heart conditions. Its most commonly known form is Viagra. Many factors can.

    Links to other sites are provided as a convenience to the viewer. Pfizer accepts no responsibility for the content of linked sites. This website is neither owned nor controlled by Pfizer. Pfizer does not endorse and is not responsible for the content or services of this site. Continue You are now leaving to enter a website neither owned nor operated by Pfizer. Links to all outside sites are provided as a resource to our visitors and do not imply an endorsement or recommendation of a particular physician by Pfizer, nor an endorsement of any Pfizer product by a telehealth provider or any physician. Pfizer accepts no responsibility or liability for the content or services of other websites. Sildenafil is used to treat men who have erectile dysfunction (also called sexual impotence). Sildenafil belongs to a group of medicines called phosphodiesterase 5 (PDE5) inhibitors. These medicines prevent an enzyme called phosphodiesterase type-5 from working too quickly. The penis is one of the areas where this enzyme works. Erectile dysfunction is a condition where the penis does not harden and expand when a man is sexually excited, or when he cannot keep an erection. When a man is sexually stimulated, his body's normal response is to increase blood flow to his penis to produce an erection. By controlling the enzyme, sildenafil helps to maintain an erection after the penis is stroked.

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    Leong Sze Hian /I refer to the licensing and registration fees for medicinal products. Before 1991, there were hardly any fees payable for the registration of medicinal products. When registration began in 1991, the per product licence fee was a year (0 for 3 years). Since the regulatory agency, the Health Sciences Authority (HSA) was created on 1 April, 2001, the fees have increased to , 0, 0, 0, maximum of up to ,500, ,500 and ,250 per first year fees, in 1992, 1996, 1998, 2003, 2006, 20, respectively. Using the maximum fee per year as a benchmark, fees have increased at a compound rate of 93 per cent per annum, over the last 10 years, since the creation of the HSA. Another example is the annual licence fee for each product licence, which increased from in 2005, to 0 and 0 in 20, respectively. This has resulted in pharmaceutical businesses reducing their product lines and is also a deterrent to expanding their product range in Singapore. Johor Bahru - share is caring - Page 390 - Buy Viagra Johor Bahru — The Biggest Healthcare Centre StCanadianPharmacy To Buy Viagra In Johor
     
  6. Ewgenij Guest

    When a man is sexually excited, the penis rapidly fills with more blood than usual. With this extra flow of blood, the penis then expands and hardens. After the man is done having sex, this extra blood flows out of the penis back into the body. In an opposite extreme situation, if an erection lasts for a long time (more than 6 hours), it can permanently damage your penis. You should call a doctor immediately if you ever have a prolonged erection that lasts more than 4 hours. Therefore sexual activity may not be advisable for people who have heart problems. Before you start any treatment for erectile dysfunction, ask your doctor if your heart is healthy enough to handle the extra strain of having sex. If you have chest pains, dizziness or nausea during sex, stop having sex and immediately tell your doctor you have had this problem. This is called erectile dysfunction if it becomes a frequent problem. Erectile dysfunction is a serious problem that can affect both the young and the old, involving psychological causes in some cases. Among other treatments that are nowadays available for erectile dysfunction, Viagra was the first. Some conditions and medicines interfere with the natural erection process. Erectile dysfunction, defined today as the inability to attain and maintain an erect penis with sufficient rigidity for sexual intercourse, has become an increasingly common complaint that affects 140 million men worldwide. So Viagra stands out as the pioneer of drugs that treat erectile dysfunction, for twenty years. Sildenafil citrate was the first oral agent to be introduced for the treatment of erectile dysfunction, thanks to the researchers from Pfizer. Sildenafil is the active substance of Viagra, while Viagra is the commercial name. Teva’s generic Viagra has launched already in December 2017 in the United States. Risk factors for developing erectile dysfunction include age, diabetes, hypertension, obesity, lack of exercise, dyslipidemia, smoking, depression, lower urinary tract symptoms, and pelvic surgery. Sildenafil is a highly selective inhibitor of PDE type 5 and enhances NO-mediated relaxation of human corpus cavernosum. Pfizer recently started to sell the new generic version of Viagra. Do food and dose timing affect the efficacy of sildenafil? A randomized. Check Out VIAGRA® sildenafil citrate Single Packs Safety Info Should I Take Viagra with Food? - Impatient - Roman
     
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