Initial: 50 mg q Day PO given continuously throughout menstrual cycle or given during luteal phase only May increase by 50 mg at the onset of each new menstrual cycle; no more than 150 mg q Day when administered continuously or 100 mg q Day when administered during luteal phase only 25 mg PO q Day initially; may increase by 25 mg every 2-3 days; not to exceed 200 mg q Day Alzheimer dementia related depression: Start at 12.5 mg/day and titrate every 1-2 weeks to response; not to exceed 150-200 mg Renal impairment: Dose adjustment not necessary Mild hepatic impairment (Child-Pugh 5-6): Decrease recommended starting dose and therapeutic dose by 50% Moderate-to-severe hepatic impairment (Child-Pugh 7-15): Not recommended; sertraline is extensively metabolized, and the effects in patients with moderate and severe hepatic impairment have not been studied Clinical worsening and suicide ideation may occur despite medication Use caution in patients with seizure disorders May worsen mania symptoms or precipitate mania in patients with bipolar disorder Increases risk of hyponatremia and impairment of cognitive/motor functions in the elderly Increases risk of bleeding in patients taking anticoagulants/antiplatelets concomitantly Risk of mydriasis; may trigger angle closure attack in patients with angle closure glaucoma with anatomically narrow angles without a patent iridectomy Pregnancy: Conflicting evidence regarding use of SSRIs during pregnancy and increased risk of persistent pulmonary hypertension of the newborn (see Pregnancy) In neonates exposed to SNRIs/SSRIs late in third trimester: Risk of complications such as feeding difficulties, irritability, and respiratory problems Avoid abrupt withdrawal Bone fractures reported with antidepressant therapy; consider the possibility if patient presents with bone pain, bruising, or point of tenderness Coadministration with other drugs that enhance the effects of serotonergic neurotransmission (eg, tryptophan, fenfluramine, fentanyl, 5-HT agonists, St. John’s Wort) should be undertaken with caution and avoided whenever possible due to the potential for pharmacodynamic interaction (see Contraindications) May cause false-positive urine immunoassay screening tests for benzodiazepines SSRIs and SNRIs are associated with development of SIADH; hyponatremia reported Several SSRIs (eg, fluoxetine, fluvoxamine, paroxetine, sertraline) are metabolized by CYP2D6 CYP2D6 is involved in the metabolism of approximately 20% of drugs in clinical use and displays large individual-to-individual variability in activity due to genetic polymorphisms More than 80 CYP2D6 variant alleles have been identified; however, 4 of the most prevalent alleles, CYP2D6*3, *4, *5, and *6, account for 93-97% of CYP2D6 poor metabolizers CYP2D6*4, the most common variant (~25% frequency in whites), causes a splicing defect; CYP2D6*3 (2.7% frequency) causes a frameshift mutation; and CYP3D6*5 (2.6%) is an entire deletion of the CYP2D6 gene; individuals homozygous for these alleles have no CYP2D6 activity The impact of CYP2D6 activity is further complicated in some SSRIs (eg, fluoxetine, fluvoxamine, paroxetine, sertraline) because in addition to being substrates for CYP2D6, they are also known to moderately inhibit CYP2D6 activity The above information is provided for general informational and educational purposes only. Individual plans may vary and formulary information changes. Contact the applicable plan provider for the most current information. Sertraline is a type of antidepressant known as a selective serotonin reuptake inhibitor (SSRI). It's often used to treat depression, and also sometimes panic attacks, obsessive compulsive disorder (OCD) and post-traumatic stress disorder (PTSD). Sertraline helps many people recover from depression, and has fewer unwanted side effects than older antidepressants. Sertraline comes as tablets, which are available only on prescription. Sertraline can be taken by adults for depression or obsessive compulsive disorder. Sertraline can be taken by children aged 6 to 17, but only for obsessive compulsive disorder. Check with your doctor before starting to take sertraline if you: If you have diabetes, sertraline can make it more difficult to keep your blood sugar stable. You can choose to take sertraline at any time, as long as you stick to the same time every day. Buy diflucan in stores Prednisone skin Valacyclovir wikipedia Viagra ingredients Oct 29, 2018. The typical starting dose is 25 or 50 mg per day. This dose can be increased on a weekly basis up to a maximum of 200 mg per day. Nov 25, 2018. Zoloft is a medication known as a selective serotonin reuptake inhibitor used to treat. The maximum recommended dosage is 200 mg per day. CNS depressants and Alcohol The co-administration of sertraline 200mg daily did not potentiate the effects of alcohol, carbamazapine, haloperidol, or phenytoin. Zoloft is a medication known as a selective serotonin reuptake inhibitor. The mediation is used to treat major depressive disorder, obsessive-compulsive disorder, panic disorder, post-traumatic stress disorder, social anxiety disorder, and premenstrual dysphoric disorder. Zoloft is a selective serotonin reuptake inhibitor (SSRI). SSRIs are the most commonly prescribed type of antidepressants, and they work by increasing levels of serotonin in the brain. They are also sometimes prescribed to treat anxiety and other conditions. If you have bipolar disorder and take an SSRI, you may be at risk for triggering a manic episode if you are not also taking a mood stabilizer. Talk to your doctor about your specific symptoms, other health concerns, and other medications you take so they can make the best recommendation for your condition and symptoms. Psychiatry Back to Psychiatry Answers List If you think you may have a medical emergency, call your doctor or 911 immediately. Doctors Lounge ( does not recommend or endorse any specific tests, physicians, products, procedures, opinions, or other information that may be mentioned on the Site. DISCLAIMER: The information provided on designed to support, not replace, the relationship that exists between a patient/site visitor and his/her physician. Please read our 'Terms and Conditions of Use' carefully before using this site. I'm going to try and make this brief...answers will be appreciated and followed up with a reply. She's been taking Zoloft for 2 years first starting with 25mg then 50mg, and as of 3 months ago 100mg. It was originally prescribed to her for helping with her OCD and fear of blood. As of 2-3 weeks ago, she has been trying to ween herself off because she's been having some very extreme panic attacks and nausea. After missing too many days of work, they've fired her. Zoloft 200 mg daily Zoloft - FDA, Zoloft sertraline hydrochloride for Depression - Metformin with glipizideAmoxicillin for toothache The data described below are from randomized, double-blind, placebo-controlled trials of ZOLOFT mostly 50 mg to 200 mg per day in 3066 adults diagnosed. Zoloft Sertraline Hcl Side Effects, Interactions, Warning, Dosage.. Sertraline 100 mg Tablets - Summary of Product Characteristics - eMC. Sertraline 50 mg daily the optimal dose in the treatment of depression.. Read about Sertraline, an antidepressant medication that is approved to treat adult major depressive disorder. The dose usually ranges from 50 mg to 200 mg. A dosage of 25 mg or 50 mg per day is the initial therapeutic dosage. increments once a week, depending on tolerability, up to a maximum of 200 mg per day. Your doctor may adjust your dose as needed. However, the dose is usually not more than 200 mg per day. Children—Use and dose must be determined by your.