Tamoxifen trial

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    Tamoxifen trial


    The Scottish Adjuvant Tamoxifen Trial (main trial) was initiated in April 1978 to assess the effect of tamoxifen given to patients with breast cancer immediately after mastectomy (or mastectomy plus radiation therapy) (adjuvant arm) or only after the patients had had a relapse (control arm); 1323 patients were randomly assigned (667 to the adjuvant arm and 656 to the control arm). Results have been reported for the follow-up period from 2.5 through 8 years. In this article, we report updated results after a median follow-up of 15 years. If agreeable and eligible, patients who were disease free at 5 years in the adjuvant arm of the main trial were entered into a duration trial and randomly assigned either to stop taking tamoxifen (169 patients) or to continue taking it indefinitely until relapse or death (173 patients). For this update, we analyzed information on death, recurrence, survival, and other malignancies for all but 21 of the 560 living patients from the original and duration trials to determine the probabilities of total survival, systemic relapse of disease, and death from breast cancer. The Scottish Adjuvant Tamoxifen Trial was initiated in April 1978. From then through September 1984, a total of 1322 patients with primary breast cancer who were aged 27–79 years agreed to participate. Each patient had received a mastectomy and had axillary lymph node clearance (levels I–III) or a lower axillary lymph node sample by which three or four lymph nodes were removed for histologic examination. The ability of a gel containing a tamoxifen-byproduct to reduce breast density — associated with an increased risk of breast cancer — is now being evaluated in a recruiting Phase 3 clinical trial. First, several studies have reported that women with dense breast tissue have a four- to six-fold increased risk of developing breast cancer, compared to women with less-dense breasts. have dense breast tissue, which has been shown to have two major health implications. Only age and mutations in genes have a bigger influence on breast cancer risk. Second, higher breast density decreases the effectiveness of cancer detection through mammography — the standard method for breast cancer detection. Dense breast tissue can mask a tumor’s presence on a mammogram. The fact that radiologists may be less confident in judging a mammography of dense breast tissue can also lead to more false-positive diagnoses. This unnecessarily exposes patients to invasive procedures, greater stress, and higher healthcare costs.

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    Background and Methods The Scottish Adjuvant Tamoxifen Trial main trial was initiated in April 1978 to assess the effect of tamoxifen given to patients with. In a blow to a promising treatment for breast cancer, a major trial of long-term treatment with the drug tamoxifen has been halted because of evidence that the. Thirty years ago, The Royal Marsden started a cancer prevention study of the drug tamoxifen, which has become one of the most important trials ever to be carried out.

    uses cookies to improve performance by remembering your session ID when you navigate from page to page. Please set your browser to accept cookies to continue. This cookie stores just a session ID; no other information is captured. Accepting the NEJM cookie is necessary to use the website. A pilot randomised placebo controlled trial using tamoxifen in healthy women at increased risk of developing breast cancer, has been undertaken in order to evaluate the problems of accrual, acute symptomatic toxicity, compliance, and safety as a basis for subsequent large national multicentre trials designed to test whether tamoxifen can chemoprevent breast cancer. From October 1986 until June 1993, 2012 healthy women with an increased risk of developing breast cancer, usually because of a strong family history, were randomly allocated to receive tamoxifen 20 mgs/day or placebo for up to 8 years if possible. Accrual remained high in spite of extensive informed consent regarding potential risk. Acute symptomatic toxicity was low for participants on tamoxifen or placebo and compliance remained correspondingly high with a predicted 77% of women on tamoxifen and 82% of women on placebo continuing medication at 5 years.

    Tamoxifen trial

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  5. A pilot randomised placebo controlled trial using tamoxifen in healthy women at increased risk of developing breast cancer, has been undertaken in order to.

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    Women with estrogen receptor-positive breast cancer who received about 5 years of adjuvant tamoxifen had a lower risk of recurrence in the 15 years after. Results of the present work represent the North American arm of the TARGET trial Tamoxifen or Arimidex Randomized Group Efficacy and. Methods. In the worldwide Adjuvant Tamoxifen Longer Against Shorter ATLAS trial, 12 894 women with early breast cancer who had completed 5 years of.

     
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