Some cells shriveled, while others took on corkscrew shapes Researchers from Jefferson Medical College in Philadelphia have found changes in brain cells in rats treated with large doses of several anti-depressant or anti-obesity drugs. A., professor of biochemistry, molecular pharmacology, anesthesiology, and neurosurgery at Jefferson Medical College of Thomas Jefferson University in Philadelphia, compared the effects of giving high doses for four days of four drugs -- Prozac, Zoloft, sibutramine (Meridia) and dexfenfluramine (Redux) -- on rat brain cells. In the study, after the toxic doses of drugs were halted, and the animals' brains subsequently examined, the researchers saw marked changes in some nerve terminals, which actively release the brain chemical serotonin. MDMA and another drug, 5,7-dihydroxytryptamine (5,7-DHT), were used as controls because both drugs push serotonin out of the brain cells. In some cases, the cells shriveled or took on abnormal corkscrew shapes. These drugs, collectively known as Selective Serotonin Reuptake Inhibitors (SSRIs), increase the level of serotonin, which is vital to brain cell communication. The brain cell changes with SSRIs were similar to those observed with MDMA. While the clinical significance of the findings isn't known, the scientists say, they may raise new concerns about the prolonged use of such commonly prescribed drugs as fluoxetine (Prozac) and sertraline (Zoloft). Low serotonin levels are linked to mood and eating disorders. Kalia and her colleagues at Jefferson and at the Centers for Disease Control and Prevention and the National Institute of Occupational Safety and Health in Morgantown, WVa., report their results March 6 in the journal Brain Research. "We don't know if results with four days of drug treatment are clinically significant," Dr. Serotonin is ubiquitous in the central nervous system, making it a frequent target of potential drugs. The work also highlights the need for similar studies on other classes of drugs that act on the central nervous system. Drugs such as Prozac and Zoloft raise serotonin levels for depression and panic attacks, for example. Methylenedioxymethamphetamine (MDMA), known as the street drug Ecstasy, is an amphetamine-derivative that is known to be toxic to some brain cells. Or they may be permanent." Prozac and Zoloft are Food and Drug Administration-approved medications for the treatment of depression and other central nervous system disorders. The anti-obesity drug Redux was pulled from the market in 1997 after reports of heart valve damage. Another class of SSRIs -- anti-anorectics -- includes drugs such as Meridia and its predecessor, Redux. A single dose of antidepressant is enough to produce dramatic changes in the functional architecture of the human brain. Brain scans taken of people before and after an acute dose of a commonly prescribed serotonin reuptake inhibitor reveal changes in connectivity within three hours, say researchers. A single dose of antidepressant is enough to produce dramatic changes in the functional architecture of the human brain. Brain scans taken of people before and after an acute dose of a commonly prescribed SSRI (serotonin reuptake inhibitor) reveal changes in connectivity within three hours, say researchers who report their observations in the Cell Press journal "We were not expecting the SSRI to have such a prominent effect on such a short timescale or for the resulting signal to encompass the entire brain," says Julia Sacher of the Max Planck Institute for Human Cognitive and Brain Sciences. While SSRIs are among the most widely studied and prescribed form of antidepressants worldwide, it's still not entirely clear how they work. The drugs are believed to change brain connectivity in important ways, but those effects had generally been thought to take place over a period of weeks, not hours. The new findings show that changes begin to take place right away. Buy propecia brand Cipro colitis May 6, 2017. “These are brain-altering drugs, and our overall experience with. when I was 12; I took a variety of SSRIs, Zoloft to Prozac to Lexapro, and. Could antidepressants really cause brain damage. A UK committee on drugs announced Prozac was the only SSRI that could be safely. Sep 18, 2014. Brain scans taken of people before and after an acute dose of a commonly prescribed SSRI serotonin reuptake inhibitor reveal changes in. We argue about treatment theories, about our clients and their families, about the office coffeepot. And during the past decade we have tended to fixate, as we say in the business, on the subject of Prozac. It used to be fairly easy to agree about commonly prescribed psychiatric drugs such as Valium: They anesthetized people, covered up problems, illegitimately took the place of therapy. But Prozac and the other antidepressants that work by enhancing serotonin activity in the brain have eluded such easy criticism. Often we would find that our clients who took them felt more alive, more resilient, more able to engage in the honest self-reflection necessary to therapy. And we could not help but agree with Peter Kramer, who wrote in Listening to Prozac that the drug can remake the self— which was supposed to be our job. Therapists haven't been alone in their Prozac anxiety. For people with depression and other mental health issues, medication can offer welcome relief. One drug commonly used to treat depression is Zoloft. Zoloft is a prescription drug that belongs to a class of antidepressants called selective serotonin reuptake inhibitors (SSRIs). Like other SSRIs, this medication works by changing how your brain cells reabsorb the neurotransmitter serotonin. If your doctor gives you this medication, you may wonder if it’s safe to drink alcohol during treatment. Read on to learn why mixing alcohol with Zoloft is not recommended. We’ll also explain the impact alcohol can have on your depression with or without medication. Zoloft brain damage Antidepressants change personality, study suggests -, Antidepressants may damage the brain Daily Mail Online Hydrocodone 7.5 325 order Jul 1, 2001. And that flood, some scientists argue, leaves brain damage in its wake. definition of neurotoxicity, because high doses of Prozac and Zoloft. The Serotonin Surprise. Single dose of antidepressant changes the brain -- ScienceDaily. What are the real risks of antidepressants? - Harvard Health. Feb 28, 2000. Researchers have found changes in brain cells in rats treated with large doses of. prescribed drugs as fluoxetine Prozac and sertraline Zoloft. was pulled from the market in 1997 after reports of heart valve damage. I started taking the Zoloft again and my symptoms disappeared, that's when I realized that I. I can't wait to find out if I have brain damage or what is going on. Zoloft is a super-common antidepressant and anti-anxiety. one of the main neurotransmitters in the brain, serotonin, which modulates mood,”.