Tamoxifen vs raloxifene

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    Tamoxifen vs raloxifene


    Bei Risikopatientinnen senken Tamoxifen und Raloxifen in gleichem Umfang das Brustkrebsrisiko. Da die beiden Wirkstoffe ein unterschiedliches Nebenwirkungsprofil aufweisen, können bei der Therapiewahl das Risikoprofil und individuelle Patientenwünsche berücksichtigt werden. Zur Prävention von Brustkrebs bei Risikopatientinnen werden selektive Estrogenrezeptor-Modulatoren (SERMs) eingesetzt. Für das ältere Tamoxifen, das auch in der Therapie des hormonrezeptorpositiven Mammakarzinoms angewandt wird, liegen mehrere Studien vor, in denen eine deutliche Abnahme des relativen Brustkrebsrisikos gezeigt wurde, und auch das jüngere Raloxifen, das bislang hauptsächlich in der Osteoporosetherapie eingesetzt wird, verfügt über ein Potenzial zur Vorbeugung von Brustkrebs. In zwei Studien wurden diese beiden Wirkstoffe direkt miteinander verglichen. Die eine Studie befasste sich mit der präventiven Potenz bei Brustkrebs und den Nebenwirkungen dieser Substanzen, die zweite mit der Lebensqualität der Probandinnen unter diesen Therapien. Präventionsstudie Die prospektive, multizentrische, randomisierte und doppelblinde NSABP-Studie (NSABP = National Surgical Adjuvant Breast and Bowel Project) wurde im Juli 1999 begonnen. JAMAJAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Facial Plastic Surgery JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Fisher B, Costantino JP, Wickerham DL. Tamoxifen for prevention of breast cancer: report of the National Surgical Adjuvant Breast and Bowel Project P-1 Study. 1998;71-13889747868Google Scholar Crossref Powles T, Eeles R, Ashley S. Interim analysis of the incidence of breast cancer in the Royal Marsden Hospital tamoxifen randomised chemoprevention trial. 1998;3-1019672274Google Scholar Cuzick J, Forbes J, Edwards R. First results from the International Breast Cancer Intervention Study (IBIS-I): a randomised prevention trial. 2002;37-82412243915Google Scholar Crossref Veronesi U, Maisonneuve P, Costa A. Differential effects of raloxifene, tamoxifen and fulvestrant on a murine mammary carcinoma. 2003;-3512779079Google Scholar Crossref Gottardis MM, Ricchio ME, Satyaswaroop PG, Jordan VC. Prevention of breast cancer with tamoxifen: preliminary findings from the Italian randomised trial among hysterectomised women. Role of raloxifene in breast cancer prevention in postmenopausal women: clinical evidence and potential mechanisms of action. 2004;0-84015262454Google Scholar Crossref Lamb CA, Helguero LA, Fabris V, Lucas C, Molinolo AA, Lanari C. Effect of steroidal and nonsteroidal antiestrogens on the growth of a tamoxifen-stimulated human endometrial carcinoma (En Ca101) in athymic mice. 1990;89-31922334915Google Scholar Delmas PD, Bjarnason NH, Mitlak BH. Effects of raloxifene on bone mineral density, serum cholesterol concentrations, and uterine endometrium in postmenopausal women. 1997;341-16479385122Google Scholar Crossref Lippman ME, Krueger KA, Eckert S. Indicators of lifetime estrogen exposure: effect on breast cancer incidence and interaction with raloxifene therapy in the multiple outcomes of raloxifene evaluation study participants. 2001;11-3116Cummings SR, Duong T, Kenyon T, Cauley JA, Whitehead M, Krueger KA. Multiple Outcomes of Raloxifene Evaluation (MORE) Trial. Bone mineral density and risk of breast cancer in older women: The Study of Osteoporotic Fractures. 1996;204-14088892715Google Scholar Crossref Martino S, Cauley JA, Barrett-Connor E. Continuing Outcomes Relevant to Evista: breast cancer incidence in postmenopausal osteoporotic women in a randomized trial of raloxifene. 2004;51-176115572757Google Scholar Crossref Kleinman D, Karas M, Danilenko M. Stimulation of endometrial cancer cell growth by tamoxifen is associated with increased insulin-like growth factor (IGF)-I induced tyrosine phosphorylation and reduction in IGF binding proteins. 1996;189-10958603578Google Scholar Crossref Gail MH, Brinton LA, Byar DP. Projecting individualized probabilities of developing breast cancer for white females who are being examined annually. 1989;79-18862593165Google Scholar Crossref Vogel VG, Costantino JP, Wickerham DL, Cronin WM, Wolmark N. Serum estradiol level and risk of breast cancer during treatment with raloxifene. 2002;26-22011779264Google Scholar Crossref Cauley JA, Norton L, Lippman ME. Continued breast cancer risk reduction in postmenopausal women treated with raloxifene: 4-year results from the MORE trial. 2001;5-13411261828Google Scholar Crossref Ettinger B, Black DM, Mitlak BH. Multiple Outcomes of Raloxifene Evaluation Investigators. Reduction of vertebral fracture risk in postmenopausal women with osteoporosis treated with raloxifene: results from a 3-year randomized clinical trial. 1999;27-64510517716Google Scholar Crossref Cauley JA, Lucas FL, Kuller LH. The study of tamoxifen and raloxifene: preliminary enrollment data from a randomized breast cancer risk reduction trial. 2002;3-15912123540Google Scholar Crossref Vogel VG, Costantino JP, Wickerham DL, Cronin WM. National Surgical Adjuvant Breast and Bowel Project update: prevention trials and endocrine therapy of ductal carcinoma in situ. 2003;5S-501S12538506Google Scholar Mc Horney CA, Ware JE Jr, Lu JF, Sherbourne CD. The MOS 36-item Short-Form Health Survey (SF-36), III: tests of data quality, scaling assumptions, and reliability across diverse patient groups. 1994;-668277801Google Scholar Crossref Mc Horney CA, Ware JE Jr, Raczek AE.

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    Breast cancer prevention drugs like tamoxifen, raloxifene and aromatase inhibitors AIs are the most commonly used drugs for preventative. A quantitative method for weighing the relative risks and benefits of tamoxifen versus raloxifene based on personal health history and. Anastrozole official prescribing information for healthcare professionals. Includes indications, dosage, adverse reactions, pharmacology and more.

    Tamoxifen and raloxifene have been shown to reduce the risk breast cancer, but they can have their own risks and side effects. Tamoxifen and raloxifene are the only drugs that are approved in the US to help lower the risk of breast cancer, although for some women, drugs called aromatase inhibitors might be an option as well. This means that they act against (or block) estrogen (a female hormone) in some tissues of the body, but act like estrogen in others. Estrogen can fuel the growth of breast cancer cells. Tamoxifen can be taken whether or not you have gone through menopause, but raloxifene is only approved for post-menopausal women. Both of these drugs block estrogen in breast cells, which is why they can be useful in lowering breast cancer risk. To lower the risk of breast cancer, these drugs are taken for 5 years. The effect of these drugs on breast cancer risk has varied in different studies. When the results of all the studies are taken together, the overall reduction in risk for these drugs is about 40% (more than a third). These drugs lower the risk of both invasive breast cancer and ductal carcinoma in situ (DCIS). Although a medicine that cuts your risk by about 40% sounds like it must be a good thing, what it would really mean for you depends on how high your risk is in the first place (your baseline risk). If you or a loved one has increased risk factors for breast cancer, developing a risk reduction plan is an important conversation to have with your doctor. At our hospital, we always recommend tackling obesity and alcohol usage first, but for those at high risk, chemoprevention can be a small piece of the risk reduction puzzle. Cancer chemoprevention is the use of drugs, either manufactured or natural, to delay or prevent the diagnosis of cancer. Breast cancer prevention drugs like tamoxifen, raloxifene and aromatase inhibitors (AIs) are the most commonly used drugs for preventative therapy. Chemoprevention does not treat malignant breast cancer if you’ve already been diagnosed. But you might be a good candidate for breast cancer prevention drugs if you have a benign (i.e. non-cancerous) disease that puts you in the high-risk category.

    Tamoxifen vs raloxifene

    Effects of Tamoxifen vs Raloxifene on the Risk of Developing., Tamoxifen or Raloxifene in Postmenopausal Women for Prevention.

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  4. For women at higher risk of breast cancer, drugs such as tamoxifen and raloxifene have been shown to help reduce the risk.

    • Tamoxifen and Raloxifene for Lowering Breast Cancer Risk.
    • Anastrozole - FDA prescribing information, side effects and uses.
    • Breast Cancer Prevention PDQ®—Health Professional Version -..

    To the Editor Dr Vogel and colleagues reported the results of the Study of Tamoxifen and Raloxifene STAR P-2 trial. I was disappointed that. Clinical trial data on selective estrogen receptor modulators SERMs and aromatase inhibitors AIs have demonstrated reduced breast cancer. Mai 2006. Darüber hinaus ergab sie aber auch, dass Raloxifen eine ebenso gute. 394 Frauen im Tamoxifen-Arm versus 313 Frauen unter Raloxifen.

     
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