Tamoxifen versus letrozole

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  1. [email protected] New Member

    Tamoxifen versus letrozole


    Accepted for publication 30 December 2015 Published 1 March 2016 Volume 2016:9 Pages 1077—1084 DOI https://doi.org/10.2147/OTT. S81087 Checked for plagiarism Yes Review by Single-blind Peer reviewers approved by Dr Jia Fan Peer reviewer comments 3 Editor who approved publication: Professor Daniele Santini School of Pharmaceutical Sciences, Jiangnan University, Wuxi, People’s Republic of China Abstract: The incidence rate of breast cancers in People’s Republic of China has increased in the last decade, and many cases are responsive to hormone therapies. The third-generation aromatase inhibitor letrozole inhibits estrogen production, and is more efficacious than the estrogen receptor inhibitor tamoxifen. In recent years, letrozole has been widely used to treat postmenopausal breast cancers in People’s Republic of China. Also, metastatic, premenopausal, and male breast cancers have been effectively treated by a combination of letrozole with cytotoxic, radiation, or other therapies. In this review, we provide a perspective and summary of recent advances in the use of letrozole for breast cancer in Chinese patients. Keywords: breast cancer, Chinese, letrozole Based on the diverse expression of estrogen receptor-α (ER-α), progesterone receptor, human epidermal growth factor receptor-2 (HER2), claudin, cytokeratin, and other molecular markers, a growing number of recognized biological subtypes of breast cancer have been identified, such as luminal A, luminal B, HER2, basal-like, and claudin-low. The antiestrogen tamoxifen has potent activity against estrogen receptor–positive breast cancer, but two nonsteroidal aromatase inhibitors, letrozole and anastrozole, show considerable advantages over tamoxifen with respect to patient survival and tolerability. To determine the optimal way to use letrozole and tamoxifen, we studied their effects on a breast tumor xenograft model, MCF-7Ca, that is responsive to both antiestrogens and aromatase inhibitors. Female ovariectomized BALB/c athymic nude mice carrying xenograft tumors were treated daily subcutaneously with one of the following first-line therapies for varying durations: no drug (control), tamoxifen (100 μg/day) alone, letrozole (10 μg/day) alone, both drugs at the same time, or alternating 4-week courses of each drug (beginning with a course of tamoxifen or beginning with a course of letrozole). Tumor volumes and weights were estimated using linear mixed-effects models. The time to tumor doubling was calculated, and tumor weights in the treatment groups were compared, with adjustments for multiple comparisons being made with either Tukey’s or Dunnett’s procedure. Second-line therapies (with tamoxifen, letrozole, or fulvestrant) were initiated when tumors doubled in size under first-line therapies. The times for doubling of tumor volume were as follows: control, 3–4 weeks; tamoxifen alone, 16 weeks; tamoxifen alternating with letrozole, 17–18 weeks; tamoxifen plus letrozole, 18 weeks; letrozole alternating with tamoxifen, 22 weeks; letrozole alone, 34 weeks. First-line treatment with letrozole was superior to treatment with tamoxifen alone or with the two drugs combined (at week 16, both First-line letrozole therapy extends time for tumor progression in this model relative to the other treatment regimens tested.

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    Nine hundred seven patients with advanced breast cancer were randomly assigned to receive 2.5 mg letrozole n = 453 or 20 mg tamoxifen n = 454 once. Dec 2, 2011. In addition, 5 years of sequential treatment—either 2 years of letrozole followed by 3 years of tamoxifen or 2 years of tamoxifen followed by 3. Nov 1, 2017. Tamoxifen is one of the most commonly used hormone therapies for breast. You are most likely to have anastrozole or letrozole for 5 years.

    Find out what hormone therapy is, when you might have it, and the possible side effects. They control the growth and activity of normal cells. Before the menopause, the ovaries produce the hormones oestrogen and progesterone. After the menopause, oestrogen is made in body fat. These hormones can stimulate the growth of some breast cancer cells. Hormone treatments lower the levels of oestrogen or progesterone in the body, or block their effects. Hormone therapy is only likely to work if the breast cancer cells have oestrogen receptors (ER). Your doctor checks your cancer cells for these receptors when you are diagnosed. Side effects of hormone therapy can include hot flashes and other menopausal symptoms.(AROMASIN/NOVARTIS/HEALTH) If your breast cancer tumor is estrogen- and/or progesterone- receptor (ER/PR) positive, that's good news because it means you have more treatment options and may benefit from hormone therapy. Tamoxifen—which has been around for decades—has been shown to prevent the chances of a recurrence in high-risk women by almost 50%. And in March 2008, researchers announced that drugs in a newer class called aromatase inhibitors (AIs) stopped breast cancer recurrence for postmenopausal patients who had completed tamoxifen treatment (even years after). In the vast majority of cases, a woman whose cancer is positive for estrogen is also positive for progesterone. "If you're positive for both, we know you will be much more responsive to anti-estrogen therapy," says Julie R. Gralow, MD, director of breast medical oncology at the University of Washington and Fred Hutchinson Cancer Research Center in Seattle. Two types of anti-estrogen drugs Tamoxifen (Nolvadex) and raloxifene (Evista) are part of a drug class called selective estrogen receptor modulators (SERMs).

    Tamoxifen versus letrozole

    What are the Side Effects of Aromatase Inhibitors Susan G. Komen®, Study Confirms Letrozole Prevents More Breast Cancer.

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  6. Dec 6, 2018. The hazard ratio for contralateral breast cancer with letrozole versus tamoxifen was 0.62 at 0 to 5 years and 0.47 at 5 to 10 years. However, this.

    • Adjuvant Letrozole and Tamoxifen Alone or Sequentially in..
    • About hormone therapy for breast cancer Cancer Research UK.
    • Hormonal Therapy for Breast Cancer Texas Oncology.

    Nov 26, 2018. Luminal breast cancer has a long natural history, with recurrences continuing beyond 10 years after diagnosis. We analyzed long-term. Oct 21, 2011. letrozole instead of tamoxifen, a long-term follow-up study shows. One group of patients took either tamoxifen or Femara for five years. The aromatase inhibitor letrozole is a more effective treatment for metastatic breast cancer and more effective in the neoadjuvant setting than tamoxifen. We compared letrozole with tamoxifen as adjuvant treatment for steroid-hormone-receptor–positive breast cancer in postmenopausal women.

     
  7. tvpmotors New Member

    into Lexapro and it's just not working for me. I just gotta clear this cloud of darkness and my doc mentioned he might switch me to Zoloft if no improvement in the Lexapro. I seem to be doing well on it along with welbutrin. take care I started off on Lexapro and had a horrible experience with it-I only stayed on it for a week and then switched to Zoloft. I appreciate anyone's experience in this regard, and/or comparison experiences. The week I was on Lexapro, my anxiety got so bad, I would curl up on the floor and just want to crawl out of my skin. Having to go thru another 3 weeks of testing another med just kills me ... I have used Zoloft for years it worked in the prior years but as for my anxiety has increased I am investigating what else to try. I couldn't carry on a conversation and my heart raced like crazy. my heart raced nonstop and my anxiety had increased, she took me off the Lexapro and switched me to Zoloft. so I'd like to think the switch to Zoloft is the right choice ... We went with Lexapro first because of it's alleged positive effects on anxiety, which I do have. Going to doctor today also the Zoloft made me gain about 10-20 pounds and it does affect your libido I had been on lexapro for awhile years back. but then I felt like It wasn't working enough. I gradually went up to 50 mg of Zoloft and I'm doing fine-I've also made some life style changes-which I would like to think has helped too. Many thanks for your shared experience and wisdom; this site is such a valuable support tool You should be feeling somewhat better. I am on zoloft and I am not doing as well as I want to be. I decided to try other meds because of tv commercials, such as cymbalta and abilify. OH and I take Klonopin as needed-I haven't really needed it in about 3 weeks. I have been on Lexapro for 1 week and it has been awful. Please keep in mind that 25 mg is pretty low, but my body couldn't even tolerate 25 mg at first. But, she started me out on 25mg, then to 50mg and I just started it on 75mg. I see some improvement, but, hopefully when I go back, I can go to 100mg and it will work fine. I've feel so much anxiety and it felt like blood was just pumping way to fast through my whole body. I broke mine in half (pill cutter) and took 12.5 mg for awhile (about a week), then eased up to 25 mg (for about 2 weeks or so) and eventually got up to 50mg. About ZOLOFT® sertraline HCl Safety Info Zoloft Side Effects CCHR International Zoloft sertraline dosing, indications, interactions, adverse effects.
     
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