Duloxetine was approved for the treatment of major depression in 2004. While duloxetine has demonstrated improvement in depression-related symptoms compared to placebo, comparisons of duloxetine to other antidepressant medications have been less successful. A 2012 Cochrane Review did not find greater efficacy of duloxetine compared to SSRIs and newer antidepressants. Additionally, the review found evidence that duloxetine has increased side effects and reduced tolerability compared to other antidepressants. It thus did not recommend duloxetine as a first line treatment for major depressive disorder, given the (then) high cost of duloxetine compared to inexpensive off-patent antidepressants and lack of increased efficacy. do not list duloxetine among the recommended treatment options. A review from the Annals of Internal Medicine lists duloxetine among the first line drug treatments, however, along with citalopram, escitalopram, sertraline, paroxetine, and venlafaxine. Duloxetine (brand names Cymbalta, Yentreve, and in parts of Europe, Xeristar or Ariclaim) is a drug which primarily targets major depressive disorder (MDD), generalized anxiety disorder (GAD), pain related to diabetic peripheral neuropathy and in some countries stress urinary incontinence (SUI). It is manufactured and marketed by Eli Lilly and Company. Duloxetine has not yet been FDA approved for stress urinary incontinence or for fibromyalgia. Duloxetine is a selective SNRI (selective serotonin-norepinephrine reuptake inhibitor). Duloxetine is a systemic drug therapy which affects the body as a whole. Known also under the code name LY248686, it is a potent dual reuptake inhibitor of serotonin (5-hydroxytryptamine, 5-HT) and norepinephrine (NE), possessing comparable affinities in binding to NE- and 5-HT transporter sites. It is a less potent inhibitor of dopamine reuptake. Sildenafil effect on females Tamoxifen fibroids Viagra how it works Doxycycline vomiting Jun 18, 2018. Learn about warnings, side effects, dosage, and more for duloxetine. mg given as 20-mg doses twice daily or 60 mg given either once daily. Duloxetine, sold under the brand name Cymbalta among others, is a medication used to treat. "Cymbalta duloxetine hydrochloride Delayed-Release Capsules for Oral Use" PDF. ^ Hershman DL, Lacchetti C, Dworkin RH, Lavoie Smith EM. Find patient medical information for Duloxetine Oral on WebMD including its uses, side effects and safety. What conditions does Duloxetine HCL treat? Review question Does duloxetine work to treat pain generated by nerves when they have been damaged in disease, or the pain caused by fibromyalgia? Background Duloxetine is a drug used to treat depression and urinary urge incontinence (leakage of urine) and it can be also be useful for certain types of pain. Pain can arise spontaneously when there is damage to nerves that carry pain information to the brain (neuropathic pain). When this damage is to nerves outside the spinal cord it is called a of all sorts. Study characteristics We looked at all the published scientific literature and found 18 trials, involving a total of 6407 participants, that were of sufficient quality to include in this . Eight trials tested the effect of duloxetine on painful diabetic neuropathy and six on the pain of fibromyalgia. Three trials treated painful physical symptoms associated with depression and one small investigated duloxetine for the pain from strokes or diseases of the spinal cord (central pain). Duloxetine is also used to treat fibromyalgia (muscle pain and stiffness) and chronic (long-lasting) pain that is related to muscles and bones. Duloxetine belongs to a group of medicines known as selective serotonin and norepinephrine reuptake inhibitors (SSNRIs). These medicines are thought to work by increasing the activity of chemicals called serotonin and norepinephrine in the brain. This medicine is available only with your doctor's prescription. Duloxetine hcl 20mg DULOXETINE HCL Pictures & Common Dosing ScriptSave WellRx, Duloxetine - Wikipedia Sertraline weightClomid 150Sertraline costsViagra risk Duloxetine Hydrochloride, Capsule, delayed release, 20 mg/1, Oral, Proficient Rx LP, 2014-06-13, Not applicable, US Us. Duloxetine hydrochloride, Capsule. Duloxetine DB00476 - Duloxetine - DrugBank. Duloxetine Oral Uses, Side Effects, Interactions, Pictures, Warnings.. Duloxetine Cymbalta NAMI National Alliance on Mental Illness. Duloxetine is used to treat depression and anxiety. It is also used for pain caused by nerve damage associated with diabetes diabetic peripheral neuropathy. Learn about Cymbalta Duloxetine Hcl may treat, uses, dosage, side effects, drug. Administer CYMBALTA at a total dose of 40 mg/day given as 20 mg twice. Duloxetine is a selective serotonin and norepinephrine reuptake inhibitor SNRI antidepressants used for treating depression, anxiety disorder, and pain.