The last dinner Wendy Dolin had with her husband, Stewart, he was so agitated that he was jiggling his leg under the table and could barely sit still. Dolin, a 57-year-old Chicago lawyer, paced up and down a train platform for several minutes and then threw himself in front of an oncoming train. Dolin soon became convinced that the drug her husband had started taking five days before his death — paroxetine, the generic form of Paxil — played a role in his suicide by triggering a side effect called akathisia, a state of acute physical and psychological agitation. He had recently started a new antidepressant but still felt very anxious. Sufferers have described feeling as if they were “jumping out of their skin.”The distress of akathisia may explain the heightened risk of suicide in some patients, some psychiatrists believe. The symptoms are so distressing, a drug company scientist wrote in the Journal of Psychopharmacology, that patients may feel “death is a welcome result.”Ms. The case is a rare instance in which a lawsuit over a suicide involving antidepressants actually went to trial; many such cases are either dismissed or settled out of court, said Brent Wisner, of the law firm Baum Hedlund Aristei Goldman, which represented Ms. The verdict is also unusual because Glaxo, which has asked the court to overturn the verdict or to grant a new trial, no longer sells Paxil in the United States and did not manufacture the generic form of the medication Mr. The company argues that it should not be held liable for a pill it did not make. Dolin sued the original manufacturer of Paxil, Glaxo Smith Kline, claiming the company had not sufficiently warned of the risks associated with the drug. Concerns about safety have long dogged antidepressants, though many doctors and patients consider the medications lifesavers. Ever since they were linked to an increase in suicidal behaviors in young people more than a decade ago, all antidepressants, including Paxil, have carried a “black box” warning label, reviewed and approved by the Food and Drug Administration, saying that they increase the risk of suicidal thinking and behavior in children, teens and young adults under age 25.“The scientific evidence does not establish that paroxetine causes suicide, suicide attempts, self-harm or suicidal thinking in adult populations,” Frances De Franco, a company spokeswoman, said in an email. “Any suicide is a tragedy, and a reminder that depression and other mental illnesses can be fatal.”Ms. Glaxo eventually reanalyzed its data, and in 2006 enhanced the warning on Paxil, cautioning that among adults of ages with major depressive disorder, “the frequency of suicidal behavior was higher in patients treated with paroxetine compared with placebo” — 6.7 times higher. Dolin’s lawsuit, however, has lifted the curtain on data from early clinical trials of Paxil, renewing concerns that older adults, who use antidepressants in far greater numbers than young people, may also be at greater risk of self-harm when taking the drugs. But that label was replaced a year later, in June 2007, by the F. A.-mandated warning now carried on all antidepressants, which says only that the increased risk has been seen among people under age 25. With all the different depression and anxiety medications on the market, it can be hard to know which drug is which. Lexapro and Zoloft are two of the more commonly prescribed medications for mood disorders such as depression. These drugs are a type of antidepressant called selective serotonin reuptake inhibitors (SSRIs). SSRIs work by increasing levels of serotonin, a substance in your brain that helps maintain your mood. Read on to learn more about similarities and differences between Lexapro and Zoloft. Lexapro is prescribed to treat depression and generalized anxiety disorder. Zoloft is prescribed to treat depression, obsessive compulsive disorder, and several other mental health conditions. Azithromycin drug interactions Ciprofloxacin tendon damage Viagra 30 day trial Zoloft sertraline, an SSRI is associated with higher rates of diarrhea than other antidepressants, and Effexor venlafaxine, another SNRI, in addition to the above mentioned increase in suicide, is more likely to increase blood pressure, heart rate, and cause nausea, and in one study was linked to gastrointestinal bleeding. Some patients taking antidepressants experience nearly intolerable agitation, a side effect that experts say may be linked to suicide. Antidepressants have also been linked to akathisia, which is extreme restlessness and an inability to sit still. The discomfort can be so great that suicide becomes a welcome alternative to feeling this type of agitation. Sertraline is used for a number of conditions, including major depressive disorder (MDD), obsessive–compulsive disorder (OCD), body dysmorphic disorder (BDD), posttraumatic stress disorder (PTSD), premenstrual dysphoric disorder (PMDD), panic disorder, and social anxiety disorder (SAD). The comparative efficacy of sertraline and TCAs for melancholic depression has not been studied. A 1998 review suggested that, due to its pharmacology, sertraline may be more efficacious than other SSRIs and equal to TCAs for the treatment of melancholic depression. A meta-analysis of 12 new-generation antidepressants showed that sertraline and escitalopram are the best in terms of efficacy and acceptability in the acute-phase treatment of adults with unipolar MDD. Sertraline used for the treatment of depression in elderly (older than 60) patients was superior to placebo and comparable to another SSRI fluoxetine, and TCAs amitriptyline, nortriptyline (Pamelor) and imipramine. Sertraline had much lower rates of adverse effects than these TCAs, with the exception of nausea, which occurred more frequently with sertraline. In addition, sertraline appeared to be more effective than fluoxetine or nortriptyline in the older-than-70 subgroup. placebo in elderly patients showed a statistically significant (that is, unlikely to occur by chance), but clinically very modest improvement in depression and no improvement in quality of life. A meta-analysis on SSRIs and SNRIs that look at partial response (defined as at least a 50% reduction in depression score from baseline) found that sertraline, paroxetine and duloxetine were better than placebo. Prozac and Zoloft are powerful prescription medications used to treat depression and other issues. The generic version of Prozac is fluoxetine, while the generic version of Zoloft is sertraline hydrochloride. Both drugs are selective serotonin reuptake inhibitors (SSRIs). Serotonin is a naturally occurring chemical that produces a feeling of well-being. These drugs work by influencing serotonin levels in your brain. By balancing chemicals in your brain, these drugs will likely improve your mood and appetite. They can also enhance your energy levels and help you sleep better. Both medications can reduce anxiety, fear, and compulsive behaviors. Zoloft suicide Zoloft - Common Side Effects, Diagnosis & Legal Claims, Another Paxil suicide. - The New York Times Amoxicillin in dogs Antidepressants alone, which have been derided as overprescribed, are used by more than 10 percent of the population 12 years and older. Among women in their forties and fifties, the rate jumps to 25 percent. Why Do Antidepressants Raise Your Suicide Risk?. Suicide And Antidepressants - DrugWatch. Lexapro vs. Zoloft What’s the difference? - Healthline. Zoloft is an antidepressant belonging to a group of drugs called selective serotonin reuptake inhibitors SSRIs. Sertraline affects chemicals in the brain that may be unbalanced in people with depression, panic, anxiety, or obsessive-compulsive symptoms. Ive been on Zoloft for 4 weeks now and I seem less depressed on most days. I have good and bad days, but SUICIDE. Zoloft and Suicide In studies, there was a slightly increased risk of suicidal thoughts or behavior in children and teenagers who took antidepressants such as Zoloft; however, it is difficult to know for sure if these antidepressants cause suicidal behavior.