Tamoxifen, also known by the brand name Nolvadex, is one of the more commonly prescribed medications to prevent breast cancer recurrence, and when used appropriately, may reduce the risk of recurrence (of breast cancer coming back) by roughly 50 percent. The drug may also be used to reduce the chance that a woman will develop breast cancer in the first place, or to slow the growth of metastatic breast cancer. Tamoxifen works by binding to estrogen receptors on breast cells so that estrogen can't bind and stimulate growth. Learn about the potential side effects, how drug interactions may occur, and how tamoxifen differs from aromatase inhibitors. estrogen-like effects, depending on the particular type of tissue in the body where it acts. It is classified as a selective estrogen receptor modulator (SERM) along with the medication Evista (raloxifene). Tamoxifen is usually not considered beneficial for those who have estrogen or progesterone negative breast cancer. But they do know that some breast cancer cells are sensitive to estrogen. In order to fuel that growth, estrogen must attach itself to those breast cancer cells. Doctors think that tamoxifen stops estrogen from attaching to the cell. No estrogen means no growth for these types of breast cancer cells. Tamoxifen also keeps healthy breast cells from growing and multiplying. That way, it also reduces the number of cells that could become cancer. In a study of more than 13,000 women at high risk for breast cancer, scientists found that women who took tamoxifen for 5 years had fewer breast cancers than women who took a placebo. Newer research suggests that taking the drug for 10 years lowers the risk even more. Xanax onset Prednisone used for Find out how doctors use hormone therapy for breast cancer. Learn about. Tamoxifen may also be used to treat advanced cancer. Tamoxifen. Evaluates the role of longer duration therapy with tamoxifen in women who completed 5 years of tamoxifen, were cancer-free, and were. A fact sheet that describes types of hormone therapy, its role in preventing and treating breast cancer, and possible side effects. side effect of tamoxifen is blood clots, including deep vein thrombosis (DVT) and pulmonary embolus. In some cases, health care professionals may use the trade name Nolvadex when referring to the generic drug name tamoxifen. This medication is classified as an "anti-estrogen." (For more detail, see "How this drug works" section below). You should seek emergency help and notify your health care provider immediately if you develop sudden chest pain and shortness of breath. Notify your health care provider within 24 hours if you notice that one leg is swollen, red, painful and/or warm to touch and the other is not. A side effect of tamoxifen can be the development of uterine cancer. Women who have not had a hysterectomy should have regular pap smears and gyn examinations. Abnormal vaginal bleeding should be reported to your health care provider. Some types of breast cancer are affected by hormones in the blood. ER-positive and PR-positive breast cancer cells have receptors (proteins) that attach to estrogen, which helps them grow. There are different ways to stop estrogen from attaching to these receptors. Hormone therapy is a form of systemic therapy, meaning it reaches cancer cells almost anywhere in the body and not just in the breast. It's recommended for women with hormone receptor-positive (ER-positive and/or PR-positive) breast cancers, and it does not help women whose tumors are hormone receptor-negative (both ER- and PR-negative). Hormone therapy is often used after surgery (as adjuvant therapy) to help reduce the risk of the cancer coming back. Sometimes it is started before surgery (as neoadjuvant therapy) as well. Hormone therapy can also be used to treat cancer that has come back after treatment or that has spread to other parts of the body. Tamoxifen therapy for breast cancer Tamoxifen Breast Cancer Care, Tamoxifen therapy for patients with breast cancer - The Lancet Azithromycin side effectsSertraline for dogsDoxycycline 300 mg for dogs Jun 27, 2017. WebMD looks at the use of the drug tamoxifen for treating breast cancer and preventing it in high-risk cases. Tamoxifen for Breast Cancer Treatment and Prevention - WebMD. Hormone Therapy for Breast Cancer Fact Sheet - National Cancer.. Risks and Benefits of Tamoxifen Therapy Cancer Network. Jan 16, 2019. How Tamoxifen Prevents Breast Cancer Recurrence. When used after primary treatment eg. surgery it may reduce your risk of breast cancer. J Clin Oncol. 1989 Jun;76803-15. Tamoxifen therapy in primary breast cancer biology, efficacy, and side effects. Love RR1. Author information Find patient medical information for Tamoxifen Oral on WebMD including its uses, side effects and safety, interactions. Tamoxifen is used to treat breast cancer.