Sertraline belongs to a class of medications known as selective serotonin reuptake inhibitors (SSRIs). It is used to treat depression, panic disorder, and obsessive-compulsive disorder (OCD). Sertraline works by affecting the balance of chemicals in the brain. Specifically, it increases the level of a neurotransmitter called serotonin in the brain. Increased serotonin levels can help improve mood, reduce panic attacks, and treat OCD. Although improvements may occur earlier, the full response to the medication may not appear until after 4 weeks of treatment or longer. This medication may be available under multiple brand names and/or in several different forms. Ativan (lorazepam) is a medication used to treat a person with anxiety or anxiety related to depression. Lorazepam is a type of medication called a benzodiazepine. It slows the activity in a person's brain, so he is The three medications work in radically different ways in the nervous system, using different receptor pathways. As always, when using a combination of drugs, poly pharmacy, better be a very good reason for do it. If you have an anxiety diagnosis (which is suggested by your interest in buspar), be aware that wellbutrin (bupropion) sometimes can aggravate anxiety. The side effects multiply with the number of medications used. Wellbutrin (bupropion) is very handy to have around for many cases of depression, add, and smoking cessation, and is usually well-tolerated. But there is that potential for aggravating anxiety. Read more See 2 more doctor answers It is generally safe to do so. Telling your doctor if you are taking any medications for sleep or that cause drowsiness is important and any other drugs that are in the same class as either zoloft (sertraline) or hydroxyzine. Read more Both Ativan and Hydroxyzine are used for Anxiety and tension. 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